Dynamics of the EEG sensorimotor and alpha rhythm amplitude patterns in a training series of controlling the power platform with visual feedback

The study of the EEG alpha reactivity patterns in the prefrontal, central, parietal and occipital regions involved 25 healthy male subjects who participated in four training sessions of controlling the power platform with visual feedback. A significant prefrontal alpha rhythm synchronization was found which was not essentially modulated in a series of subsequent trainings. A significant desynchronization of the occipital alpha was registered for the second session which gradually increased up to the fourth session. The sensorimotor alpha rhythm didn’t show regular patterns. The use of the dominant (right) hand resulted in a significant desynchronization of the parietal alpha in the right hemisphere in the third and the fourth training sessions

Coordinating metal Mn

The paper researches the effect of manganese (АCMn2+) and nickel (АCNi2+) acetylsalicylates in doses of 5 and 10 mg/kg on the characteristics of the rats’ cardiorespiratory system. It is ascertained that coordinating metal compounds with the acetylsalicylic acid have a more pronounced biological effect in comparison with a monocompound of the acetylsalicylic acid; this makes the further search for coordinating compounds’ effects more promising

Psychoactive effects of “Enoant” and “Resveratrol” in Wistar rats of both sexes

The effect of two supplements containing resveratrol (“Resveratrol” and “Enoant”) on the psycho-emotional state of animals with an initial index of anxiety and depression above 0.5 was studied. For this, the “Elevated plus maze” (EPM) and “Forced swim test” (FST) were used. “Resveratrol” significantly reduces the index of depressivity (ID) in males on the 7th and 14th days of application, in females – only on the 14th day. No significant influence on the anxiety index (AI) was found in both sexes. “Enoant” significantly reduces the ID in males on the 7th day, but not on the 14th day, while no significant differences were observed in females. However, unlike “Resveratrol”, “Enoant” significantly reduces the AI on the 14th day in rats of both sexes

Effects of Dimephosphone on skin survival in conditions of reduced blood circulation

Introduction: The search for and creation of drugs with dermatoprotective and metabotropic activity is one of the priorities of modern diabetology. Synthetic organophosphorus compounds with no anticholinesterase activity, to which Dimephosphone belongs to, deserve great attention in this respect. Materials and Methods: Experiments included 355 white non-linear male mice (18-34 g) and 799 male rats (150–305 g). The dermatoprotective activity (DPA) of Dimephosphone regarding the survival of a skin graft was studied against the background of normoglycemia, as well as against the background of experimental diabetes complicated by hypercholesterolemia. The study of microhemodynamics in the skin was performed using laser Doppler flowmetry. The effects on metabolic processes and the antioxidant system were studied by determining the levels of glucose, urea, creatinine, total bilirubin, total cholesterol, triglycerides, total protein, albumin, globulin, catalase, malondialdehyde, superoxide dismutase, glutathione reductase, glutathione and glutathione peroxidase. Results: Dimephosphone has a pronounced DPA in conditions of reduced blood circulation against the background of normoglycemia and experimental (alloxan) diabetes complicated by exogenous hypercholesterolemia. By DPA, in most cases against the background of normoglycemia Dimephosphone exceeds Actovegine, is comparable to or inferior to Trental and Mexidol, and is more significant in terms of the therapeutic width than all the drugs taken for comparison. Discussion: According to the obtained data , DPA of Dimephosphone may be due to its ability to exhibit significant vasodilating, antihypoxic, antioxidant, antiaggregant, membrane-stabilizing, anti-acidotic, antimicrobial and other properties and also to exert a normalizing effect on carbohydrate, protein, lipid and energy metabolism Conclusion: Dimephosphone can be recommended for further preclinical and clinical studies in the form of various dosage forms, as well as in a combination therapy for metabolic disorders

Mafusol and its combination with REXOD as correctors of reduced blood circulation in the skin associated with normoglycemia or diabetes mellitus complicated by exogenous hypercholesterolemia

Introduction: The search for and development of new highly active medications and their combinations of the appropriate direction of action remains an urgent problem due to the complications of diabetes mellitus, especially burdened with atherosclerosis, including skin and vascular lesions. Materials and methods: The acute toxicity, histoprotective and dermatoprotective effects of mafusol, rexod, alprostadil and their combinations were studied in male rats with normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Results: The combination of mafusol with rexod is less toxic than mafusol. In arteriovenous insufficiency of the tail, ischemia of the skin fold and skin flap, mafusol (6.25, 12.5 and 25.0 mg/kg in terms of fumarate), rexod (0.01 and 0.02 mg/kg) and especially their combination (6.25 and 0.01 mg/kg) have significant histoprotective, dermatoprotective, hypoglycemic and lipid-lowering effects, both in normoglycemia and alloxan diabetes complicated by exogenous hypercholesterolemia. Alprostadil (10 mg/kg) and especially its combination with mafusol (6.25 mg/kg) have a dermatoprotective effect. Discussion: Rexod reduces the acute toxicity of mafusol. The dermatoprotective effect of mafusol, rexod and, to a greater extent, their combination may be associated with increased microhemocirculation, antihypoxic properties and activation of energy processes in the skin, normalization of carbohydrate and lipid metabolism in alloxan diabetes, complicated by exogenous hypercholesterolemia, increased reserve capacity of the antioxidant system, and possibly with the ability of mafusol and rexod to reduce blood viscosity and improve rheological properties of the blood. The combination of mafusol with alprostadil increases the dermatoprotective activity of the latter. Conclusion: Combinations of mafusol with rexod and alprostadil can be recommended for clinical study as dermatoprotective agents for treating traumatic injuries and diabetes mellitus complicated by atherosclerosis