The association of rs12444979 and rs2241423 genotype combination with the risk of uterine hyperplastic processes

A lot of women of fertile and predecidual age have hyperplastic processes of endometrium having a risk of malignization in 10-50% of cases. The present study investigated an association between rs12444979 and rs2241423 polymorphisms and risk of uterine hyperplastic processes in Russian wome

Association of genetic polymorphisms rs4374421, rs7759938 and rs466639 with uterine hyperplastic processes

Uterine hyperplastic processes such as of endometrium, uterine leiomyoma, genital endometriosis are mostly common pathological conditions among gynaecological diseases. The disorders have shared pathogenetic mechanisms and may be diagnosed in combination

Pharmacogenetic study of lipid-lowering therapy with rosuvastatin in coronary artery disease patients

Polymorphic genes involved in the regulation of lipid metabolism may be responsible for interindividual differences in efficiency of hypolipidaemic therapy. In the present prospective and randomised study, we investigated the efficacy of rosuvastatin (10 mg/day) in lipid-lowering therapy in 62 patients with coronary artery disease (CAD) possessing different genotypes of lipoprotein lipase (LPL) gen

Ancient human genomes suggest three ancestral populations for present-day Europeans

We sequenced the genomes of a 7,000-year-old farmer from Germany and eight 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes¹-₄ with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations:west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians³, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry.We model these populations’ deep relationships and show that early European farmers had 44% ancestry from a ‘basal Eurasian’ population that split before the diversification of other non-African lineage

Study of the associations between polymorphic markers rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes = Изучение ассоциаций полиморфных маркеров генов факторов некроза опухоли и их рецепторов rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 с формированием сахарного диабета 2 типа

To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russi

The contribution of MTHFR C677T polymorphism to peripheral artery disease in diabetic patients

The aim of this study was to investigate the association between functional polymorphism C677T (rs1801133) of methylenetetrahydrofolate reductase (MTHFR) gene for and risk of peripheral artery disease in diabetes patient

Association study of genetic polymorphisms of vasoactive hormones with the risk of preeclampsia

The present study was designed to investigate an association of genetic polymorphisms of vasoactive hormones with the risk of preeclampsi

Bioinformatic Analysis of the Liability to the Hyperplastic Processes of the Uterus

This paper presents the results of bioinformatic analysis of five molecular genetic markers of 947 women with uterine hyperplasia and 988 women of the control grou

The etiopathogenesis of uterine leiomyomas: A review

To summarize the available literature data on the etiopathogenesis of uterine fibroids as well as the risk factors for the development of this diseas

Maternal polymorphic loci of rs1979277 serine hydroxymethyl transferase and rs1805087 5-methylenetetrahydrofolate are correlated with the development of fetal growth restriction: A case-control study

To study the relationship between polymorphisms of folate cycle genes in the mother with the development of fetal growth restriction (FGR