The association of rs12444979 and rs2241423 genotype combination with the risk of uterine hyperplastic processes

A lot of women of fertile and predecidual age have hyperplastic processes of endometrium having a risk of malignization in 10-50% of cases. The present study investigated an association between rs12444979 and rs2241423 polymorphisms and risk of uterine hyperplastic processes in Russian wome

Association of genetic polymorphisms rs4374421, rs7759938 and rs466639 with uterine hyperplastic processes

Uterine hyperplastic processes such as of endometrium, uterine leiomyoma, genital endometriosis are mostly common pathological conditions among gynaecological diseases. The disorders have shared pathogenetic mechanisms and may be diagnosed in combination

Pharmacogenetic study of lipid-lowering therapy with rosuvastatin in coronary artery disease patients

Polymorphic genes involved in the regulation of lipid metabolism may be responsible for interindividual differences in efficiency of hypolipidaemic therapy. In the present prospective and randomised study, we investigated the efficacy of rosuvastatin (10 mg/day) in lipid-lowering therapy in 62 patients with coronary artery disease (CAD) possessing different genotypes of lipoprotein lipase (LPL) gen

The relationship between the - 344С˃T polymorphism of gene encoding aldosterone synthase and the prothrombin time in patients with intracerebral hemorrhage

Gene encoding aldosterone synthase gene (CYP11B2), has been suggested to contribute to stroke. The present study was designed to investigate whether common functional polymorphism −344C>T (rs179998) of the CYP11B2 gene is associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH) in a Russian populationyesBelgorod State National Research Universit

Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension

Association of polymorphic markers rs243865 and rs3025058 with the development of arterial hypertension Essential hypertension is a multifactorial polygenic disease with a highest incidence in the world. The purpose of the study was to assess the relationship between gene polymorphisms MMP2-1586S>T (rs243865) and -1612 5A/6A MMP3 (rs3025058) with the development of arterial hypertension in population of the Central Chernozem region of Russi

Study of the associations between polymorphic markers rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes = Изучение ассоциаций полиморфных маркеров генов факторов некроза опухоли и их рецепторов rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 с формированием сахарного диабета 2 типа

To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russi

Genetic association between the CYBA 640A>G polymorphism and the risk of uterine myoma

The aim of this study was to investigate the association between functional polymorphism 640A>G (rs1049255) of the CYBA (cytochrome b-245, alpha polypeptide of NADPH oxidase) gene and the risk of uterine myom

The genetic history of admixture across inner Eurasia

Eurasian taiga and tundra - harbour tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 bp

Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data

Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliationyesBelgorod State National Research Universit

Search for molecular-genetic markers of risk germination hyperplastic processes in endometry combined with hysteromyoma

The results of studies of uterine fibroids in women. Studies on the role of combinations molecular-genetic markers of cytokines in germination hyperplastic processes combined with hysteromyoma are part of this studyye