Violence by clients towards female prostitutes in different work settings: questionnaire survey

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Low-Mass X-ray Binaries and Globular Clusters in Early-Type Galaxies. I. Chandra Observations

We present a Chandra survey of LMXBs in 24 early-type galaxies. Correcting for detection incompleteness, the X-ray luminosity function (XLF) of each galaxy is consistent with a powerlaw with negative logarithmic differential slope, beta~2.0. However, beta strongly correlates with incompleteness, indicating the XLF flattens at low-Lx. The composite XLF is well-fitted by a powerlaw with a break at 2.21(+0.65,-0.56)E38 erg/s and beta=1.40(+0.10,-0.13) and 2.84(+0.39,-0.30) below and above it, respectively. The break is close to the Eddington limit for a 1.4Msun neutron-star, but the XLF shape rules out its representing the division between neutron-star and black-hole systems. Although the XLFs are similar, we find evidence of some variation between galaxies. The high-Lx XLF slope does not correlate with age, but may correlate with [alpha/Fe]. Considering only LMXBs with Lx>1E37 erg/s, matching the LMXBs with globular clusters (GCs) identified in HST observations of 19 of the galaxies, we find the probability a GC hosts an LMXB is proportional to LGC^alpha ZFe^gamma} where alpha=1.01+/-0.19 and gamma=0.33+/-0.11. Correcting for GC luminosity and colour effects, and detection incompleteness, we find no evidence that the fraction of LMXBs with Lx>1e37 erg/s in GCs (40%), or the fraction of GCs hosting LMXBs (~6.5%) varies between galaxies. The spatial distribution of LMXBs resembles that of GCs, and the specific frequency of LMXBs is proportional to the GC specific luminosity, consistent with the hypothesis that all LMXBs form in GCs. If the LMXB lifetime is tau and the duty cycle is Fd, our results imply ~1.5 (tau/1E8 yr)^-1 /Fd LMXBs are formed per Gyr per GC and we place an upper limit of 1 active LMXB in the field per 3.4E9Lsun of V-band luminosity.Comment: 24 pages, 17 figures and 6 tables. Accepted for publication in the Astrophysical Journal. Expanded discussion and various minor revisions to improve robustness of results. Conclusions unchange

Identification of the soft X-ray excess in Cygnus X-1 with disc emission

We present results of a study of the soft X-ray excess in the black hole candidate Cygnus X-1 made with the {\it Rosat PSPC}, using observations taken during persistent emission at orbital phases close to 0.5. The soft excess can be well fitted as a blackbody with temperature $\rm {kT_{bb}}$ = $\rm {0.13\pm 0.02}$ keV. $\rm {kT_{bb}}$ did not vary appreciably with intensity of the source. By assuming that the distance of the source is its lower limit of 2.5 kpc, a luminosity of the soft excess of $\rm {4.7\cdot 10^{36}}$ erg $\rm {s^{-1}}$ was obtained. From this, disc temperatures were calculated as a function of radius, assuming the compact object to be a 10 \rm{M_{\sun}} black hole, in particular, the temperature at 7 Schwarzschild radii expected to be highly representative of the total disc emission. This was found to be 0.13 keV, in very good agreement with the spectral fitting result. This good agreement strongly supports the identification of the soft excess with emission from the disc around a black hole.Comment: PostScript, 3 figures, accepted for publication Astronomy and Astrophysics Lette

The Ephemeris and Dipping Spectral Behavior of X1624-490

We present striking results from Rossi X-ray Timing Explorer (RXTE) observations of the 21-hr low mass X-ray binary X1624-490, showing five complex dips in unprecedented detail. For the first time, dipping is detected up to 15 keV. Prominent flares are also observed in the light curves, limited to energies above 8 keV. Spectra selected by intensity during dip episodes can be well fit with a two-component model consisting of a point-like blackbody from the neutron star and progressive covering of an extended Comptonized region, presumably an accretion disk corona (ADC), corrected for photons scattered into and out of the X-ray beam by a interstellar dust halo. We find that the outer regions of the absorber are highly ionized and that electron scattering is totally responsible for the X-ray attenuation during shallow dipping. The timescales of dip ingress and egress indicate that the envelope of material absorbing the ADC has smaller angular size than the ADC itself, and that the ADC is likely limited to a height-to-radius ratio of 10%, rather than being spherical in extent. In addition, we have analyzed 4.5 yrs of RXTE All Sky Monitor (ASM) coverage to derive the first accurate orbital ephemeris for X1624-490, with phase zero (the time of dip centers) well-described by the relation 2450088.63918(69) + N*0.869907(12) (JD).Comment: 12 pages, 5 figure

Chandra HRC Localization of the Low Mass X-ray Binaries X1624-490 and X1702-429: The Infrared Counterparts

We report on the precise localization of the low mass X-ray binaries X1624-490 and X1702-429 with the Chandra HRC-I. We determine the best positions to be 16:28:02.825 -49:11:54.61 (J2000) and 17:06:15.314 -43:02:08.69 (J2000) for X1624-490 and X1702-429, respectively, with the nominal Chandra positional uncertainty of 0.6". We also obtained deep IR observations of the fields of these sources in an effort to identify the IR counterparts. A single, faint (Ks=18.3 +/- 0.1) source is visible inside the Chandra error circle of X1624-490, and we propose this source as its IR counterpart. For X1702-429, a Ks=16.5 +/- 0.07 source is visible at the edge of the Chandra error circle. The brightness of both counterpart candidates is comparable to that of other low mass X-ray binary IR counterparts when corrected for extinction and distance.Comment: 5 pages, 2 figures, accepted for publication in Ap

An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK

This study aimed to estimate the prevalence of canine diabetes mellitus (DM) in primary-care clinics in England, to identify risk factors associated with DM and to describe the survival of affected dogs. Cases of DM were identified within the electronic patient records of 89 small-animal practices. A nested case–control study identified risk factors for the diagnosis of DM using logistic regression models. Cox proportional hazards models were used to analyse variables associated with survival. Four-hundred and thirty-nine canine DM cases were identified, giving an apparent prevalence of 0.34% (95% CI 0.31% to 0.37%). Neutered males were at an increased risk of diabetes compared with entire males, whereas neutering was not associated with DM in females. When compared with crossbred dogs, Yorkshire terriers had increased odds, whereas German shepherd dogs and golden retrievers had lower odds of DM. Being classified as overweight and having a diagnosis of pancreatitis, hyperadrenocorticism or a urinary tract infection were positively associated with DM. Older dogs and those diagnosed with pancreatitis had a higher hazard of death, whereas insured and neutered dogs had a lower hazard. This study provides an objective assessment of canine DM using primary-care veterinary practice data and is a valuable benchmark against which future epidemiological trends in DM can be assessed and improvements in the management of DM in primary-care practice can be judged

Comparing external ventricular drains-related ventriculitis surveillance definitions

OBJECTIVETo evaluate the agreement between the current National Healthcare Safety Network (NHSN) definition for ventriculitis and others found in the literature among patients with an external ventricular drain (EVD)DESIGNRetrospective cohort study from January 2009 to December 2014SETTINGNeurology and neurosurgery intensive care unit of a large tertiary-care centerPATIENTSPatients with an EVD were included. Patients with an infection prior to EVD placement or a permanent ventricular shunt were excluded.METHODSWe reviewed the charts of patients with positive cerebrospinal fluid (CSF) cultures and/or abnormal CSF results while they had an EVD in place and applied various ventriculitis definitions.RESULTSWe identified 48 patients with a total of 52 cases of ventriculitis (41 CSF culture-positive cases and 11 cases based on abnormal CSF test results) using the NHSN definition. The most common organisms causing ventriculitis were gram-positive commensals (79.2%); however, 45% showed growth of only 1 colony on 1 piece of media. Approximately 60% of the ventriculitis cases by the NHSN definition met the Honda criteria, approximately 56% met the Gozal criteria, and 23% met Citerio’s definition. Cases defined using Honda versus Gozal definitions had a moderate agreement (κ=0.528; P&lt;.05) whereas comparisons of Honda versus Citerio definitions (κ=0.338; P&lt;.05) and Citerio versus Gozal definitions (κ=0.384; P&lt;.05) had only fair agreements.CONCLUSIONSThe agreement between published ventriculostomy-associated infection (VAI) definitions in this cohort was moderate to fair. A VAI surveillance definition that better defines contaminants is needed for more homogenous application of surveillance definitions between institutions and better comparison of rates.Infect Control Hosp Epidemiol 2017;38:574–579</jats:sec

Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells

Monoamine oxidases (MAOs) are mitochondrial enzymes which control the levels of neurotransmitters in the brain and dietary amines in peripheral tissues via oxidative deamination. MAO has also been implicated in cell signalling. In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosporine (STS) in human dopaminergic neuroblastoma cells (SH-SY5Y). Increased levels of MAO-A activity were induced by STS, accompanied by increased MAO-A protein and activation of the initiator of the intrinsic pathway, caspase 9, and the executioner caspase 3. MAO-A mRNA levels were unaffected by STS, suggesting that changes in MAO-A protein are due to post-transcriptional events. Two unrelated MAO-A inhibitors reduced caspase activation. STS treatment resulted in sustained activation of the mitogen-activated protein kinase pathway enzymes extracellular regulated kinase, c-jun terminal kinase and p38, and depletion of the anti-apoptotic protein Bcl-2. These changes were significantly reversed by MAO inhibition. Production of reactive oxygen species was increased following STS exposure, which was blocked by both MAO inhibition and the antioxidant N-acetylcysteine. Therefore our data provide evidence that MAO-A, through its production of reactive oxygen species as a by-product of its catalytic activity on the mitochondrial surface, is recruited by the cell to enhance apoptotic signalling