Cyclotrimerization of 3-R-1,2,4-triazin-5(4H)-ones with cyclic ketones

New heterocyclic tetracyclic systems were synthesized. Interaction between 3-R-1,2,4-triazin-5(4H)-ones and cyclic ketones under acidic conditions leads to the formation of zwitterion derivatives of 5,6,7,8,9,10,11,12-octahydro-[1,2,4] triazino[1,6- f ]phenanthridine and 1,2,3,6,7,8-hexahydro-bicyclopenta[b,d] pyrido[1,2- f ][1,2,4]triazine. © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen

Chemodivergence in Metal-Catalyzed Cross-Dehydrogenative Coupling Reactions of 2H-imidazole 1-oxides with 1H-pyrrole

This work was supported by the Russian Science Foundation (Project # 18-73-00088)

Synthesis of chiral ferrocenylazines. Negishi cross-coupling or S N H reactions?

Preparation of new hetaryl-containing planar chiral ferrocene by a nucleophilic substitution of hydrogen in azines was performed using a lithium derivative of (S)-ferrocenyl-p-tolylsulfoxide as s nucleophilic reagent © 2013 Pleiades Publishing, Ltd

Synthesis of 4-hydroxy and 6-hydroxyindoles: a renaissance of the Bischler reaction

In the present work we studied a modified Bischler-Möhlau reaction – synthesis of indoles from benzoin and aniline. Our proposed modification of this method differs from that described earlier in that the reaction is carried out at a lower temperature, which makes it possible to improve yields and reduce formation of tarry side products. In addition, unlike the previous contradictory works, which described the preparation of a single 4-hydroxy or 6-hydroxy isomer in condensation of m-aminophenol and benzoin, we obtained both 4-hydroxy and 6-hydroxy isomers

Synthesis of nitroxyl radical by direct nucleophilic functionalization of a C-H bond in the azadiene systems

Cyclic dinitrones underwent nucleophilic substitution of the hydrogen atom in the reaction with a paramagnetic carbanion, the lithium derivative of 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl 3-oxide, to give polyfunctional nitronyl nitroxyls. © 2012 Springer Science+Business Media New York

Cyclic peroxides and related initiating systems for radical polymerization of methyl methacrylate

Cyclic peroxides as initiators for the radical polymerization of methyl methacrylate were proposed. The initial rates, initiation rates, and effective activation energies of polymerization initiated by cyclic peroxides and cyclic peroxide-1-pyridyl-2-ferrocene systems were determined. The radical yields to the volume upon the thermal decomposition of cyclic peroxides and their catalytic decomposition in the presence of 1-pyridyl-2-ferrocene were determined. In combination with 1-pyridyl-2-ferrocene cyclic peroxides form efficient initiating systems favoring an increase in the polymerization rate, a decrease in the molecular weights, and an increase in syndiotacticity of the synthesized poly(methyl methacrylate). © 2013 Springer Science+Business Media New York

Nucleophilic Addition of Indoles to Carborancarboxaldehyde – a Convinient Synthetic Strategy Towards Novel Boron-Enriched 3-Indolylmethanols

This work was supported by Russian Science Foundation (Project 18-13-00365)

Nucleophilic Substitution of Hydrogen (SNH) as a Synthetic Approach Towards Pentafluorophenyl SubstituteD 2himidazoles, 1,2,3-triazoles and its N-oxides

The study was carried out with the financial support of the Russian Science Foundation as part of a research project 18-73-00088

Synthesis of acyclic nucleoside analogues by one-step Vorbrüggen glyco-sylation of 1,2,4-triazolo[1,5-a]pyrimidine-7-ones

New analogues of acyclovir have been prepared by reacting 1,2,4 -triazolo[1,5-a]pyrimidin-7-ones 1а-i and (2-acetoxyethoxy)methyl acetate 2 in the presence of trimethylsilyl trifluoromethanesulfonate as a catalyst. The interaction between the compounds 1а-е and 2 has led to a mixture of N3 and N4 isomers. In contrast, the reaction of compounds 1g-i and 2 proceeded selectively to form N3 isomers. In the case of compounds 1a-c the predominant product is the one with the acyclic moiety in azine ring (N4 isomer). Interaction between 1d-f and 2 has led to mixtures comprising mainly N3 isomer. It has been found that the ratio of glycosylation products 1 and 2 are thermodynamically controlled. The structure of the obtained compounds has been proved by 1Н, 13С, two-dimensional 1Н-13С NMR spectroscopy and X-ray analysis