The Motivation Theory of Life-Span Development and Its Implications for Career Education

Based on the Selective Optimization with Compensation (SOC) and control model, the Motivational Theory of Life-Span Development (MTLSD) proposes adaptive development criteria and objectives. It asserts that the pursuit of perpetual development is the primary control and that the life cycle is an action field with an opportunity and constraint structure of time organization. Opportunity is a process characterized by the change processes of escalating and waning and by the adaptation consistency processes of goal participation and goal separation. The MTLSD has endeavored to elucidate how people actively promote their own personal lifelong development throughout its entirety. This provides illumination for China’s career education. The importance of individual initiative in career development, the process of opportunity in the continuity of career education, the difference of career education in different career (major) life cycles, and the fairness of career education during the transitional period of social mobility (opportunity) must be emphasized

Career adapt-ability scale -short form: Validation among early career stage of Chinese university graduates

The Career Adapt-Ability Scale (CAAS) is the favored method among researchers for measuring career adaptability. The 12-item version of CAAS-SF, which was made by Maggiori, Rossier, and Savickas based on a change to CAAS, has been slowly used by different groups in different countries and regions. As samples for the validation of the scale in this study, 571 Chinese university graduates in the early stages of their professions were chosen. Principal component analysis and confirmatory factor analysis suggest that CAAS-SF and CAAS have very similar psychological measurement features and factor structures. And the internal consistency of each subscale and total scale are equivalent to or greater than that of the CAAS assessment. These findings indicate that the CAAS-SF is a valid and reliable instrument for evaluating China’s career adaptability. In addition, limitations, issues for further research, and suggestions are emphasized

The Construction of Career Education in Senior High School under the Field Perspective

In the deep-seated transformation of senior high school education catalysed by the reform of the college entrance examination, the function of career education in senior high school has garnered attention. This paper examines career education in senior high school through the lens of Bourdieu's theory of the field. It is not only significant for theoretical reconstruction but also for re-understanding of methodology. It highlights the necessity of viewing the propelling role of capital and power, particularly cultural capital, from a relational perspective within its structural context. In addition, the process is examined in terms of the significance of the distinct habits that shaped its construction and practical logic. The career field in senior high school emphasize ‘value leadership’ and ‘personal growth’, moulding field habits through the interplay of relationships within the field and interactions with other fields, such as the ‘college field’ and the ‘workplace field’. This interaction contributes to the development of field behaviours and stimulates the psychological field's growth and transformation. It aids actors in generating their patterns of practice, thereby attaining the dual objectives of intellectual and social construction and development

Impact of Laser Intensity Noise on Dual-Comb Absolute Ranging Precision

Noise in mode-locked lasers has been a central issue for dual-comb metrological applications. In this work, we investigate the laser intensity noise on dual-comb absolute ranging precision. Two different dual-comb schemes based on linear optical sampling (LOS) and nonlinear asynchronous optical sampling (ASOPS) have been constructed. In the LOS scheme, the ranging precision deteriorates with the increase in laser relative intensity noise (RIN). This effect can be corrected by implementing a balanced photo-detection (BPD). In the ASOPS scheme, the experiment shows that the conversion from laser RIN to dual-comb ranging precision is negligible, making a balanced detection unnecessary for ranging precision improvement. The different manners of RIN’s impact on absolute ranging precision are attributed to the distinct cross-correlation signal patterns and the underlying time-of-flight (TOF) extraction algorithms

Compression–compression fatigue behaviour of gyroid-type triply periodic minimal surface porous structures fabricated by selective laser melting

Triply Periodic Minimal Surface (TPMS) porous structures are recognized as the most promising bionic artificial structures for tissue engineering. The fatigue properties of additive manufactured porous structures are essential for long-term use in a dynamical bio-skeletal environment. The aim of this study is to study the compression–compression fatigue behaviour and the underlying fatigue mechanism of Gyroid cellular structures (GCS), a typical TPMS porous structure. The high-cycle fatigue results show that both cyclic ratcheting and fatigue damage phenomena contribute to the failure of GCS during fatigue testing. For most fatigue loading stress, the failure samples have nearly 45° fracture bands along the diagonal surface. The fatigue ratio of GCS reaches 0.35 for as-built samples and can be raised to 0.45 after sandblasting treatment. The fatigue ratio values are higher than most of the other bending-dominated lattice structures, suggesting superior fatigue resistance properties of GCSs due to the smooth surface connection between struts. Besides, a systematic investigation of the crack initiation and propagation was conducted by both deformation analysis and finite element method to support experimental phenomena. The results also indicate that the fatigue resistance properties of GCSs are significantly enhanced by sandblasting post-treatment, through removing the adhered powder particles, inducing compressive residual stress on the surface and generating a nanocrystalline zone.</p

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3

Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon carcinoma. Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3. Consequently, we find that lycorine exhibits anti-proliferative activity and induces cell apoptosis on human colorectal cancer (CRC) in vitro. Lycorine induces the activation of the caspase-dependent mitochondrial apoptotic pathway, as indicated by activation of caspase and increase of the ratio of Bax/Bcl-2 and mitochondrial depolarization. Overexpressing STAT3 greatly blocks these effects by lycorine in CRC cells. Finally, lycorine exhibits a potential therapeutic effect in xenograft colorectal tumors by targeting STAT3 without observed toxicity. Taken together, the present study indicates that lycorine acts as a promising inhibitor of STAT3, which blocks tumorigenesis in colon carcinoma

Table_1_Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3.DOCX

<p>Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon carcinoma. Lycorine selectively inactivates phospho-STAT3 (Tyr-705), and subsequent molecular docking uncovers that lycorine directly binds to the SH2 domain of STAT3. Consequently, we find that lycorine exhibits anti-proliferative activity and induces cell apoptosis on human colorectal cancer (CRC) in vitro. Lycorine induces the activation of the caspase-dependent mitochondrial apoptotic pathway, as indicated by activation of caspase and increase of the ratio of Bax/Bcl-2 and mitochondrial depolarization. Overexpressing STAT3 greatly blocks these effects by lycorine in CRC cells. Finally, lycorine exhibits a potential therapeutic effect in xenograft colorectal tumors by targeting STAT3 without observed toxicity. Taken together, the present study indicates that lycorine acts as a promising inhibitor of STAT3, which blocks tumorigenesis in colon carcinoma.</p