ANM Discovery–SNPs associated with age at natural menopause (ANM) in African American women from the PAGE Study.

<p>Tests of association at p≤1E-04 from single SNP linear regressions adjusted for study site and principal components in 1,860 African American women from the PAGE Study are shown. For each significant test of association, the chromosome, rs number, nearest gene, location, coded allele, beta, standard error (SE), and p-value are given. Genes listed are nearest genes to the SNP as measured from the transcription start site for upstream SNPs or the transcription stop site for downstream SNPs. Abbreviations: CAF, coded allele frequency.</p

Regional Association Plots for Age at Menarche in African American women in the PAGE Study.

<p>Locus Zoom plots for selected gene regions in age at menarche analysis. Vertical axis is –log₁₀ of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with age at natural menopause in 1,860 African American women from the PAGE Study. Approximate linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r² legend in each plot. (A) Locus Zoom plot for the <i>CYP19A1</i> region, with rs10519297 the most significant SNP in the region. (B) Locus Zoom plot for the <i>FTO</i> region; rs2689243 was the most significant SNP in the plot region. (C) <i>LIN28B</i> region Locus Zoom plot; rs408949 was the most significant SNP in the plot region. (D) Locus Zoom plot of the <i>CYP1B1</i> region; rs13391045 was the most significant SNP in the plot region.</p