2 research outputs found
Brighter, More Stable, and Less Toxic: A Host–Guest Interaction-Aided Strategy for Fabricating Fluorescent Silica Nanoparticles and Applying Them in Bioimaging and Biosensing at the Cellular Level
The exploration of
fluorescent tools with distinguished optical properties and favorable
biocompatibility is significant for biosensing and bioimaging. We
herein present a host–guest interactions aided strategy for
fabricating fluorescent silica nanoparticles (FSNPs), which is enabled
by cyclodextrin (CD) supermolecules. Compared with conventional FSNPs,
the modified products (are named as fluorophore@CD@SNPs) possess several
advantages. First, the incorporated fluorophores can thoroughly get
rid of their intrinsic aggregation due to CD’s inclusion effect,
and the fluorescence intensity of the obtained fluorophore@CD@SNPs
can enhance 48–67%. The fluorophores can then be well-fixed
by the host CD molecules. As a result, the leak rates of the incorporated
fluorophores are only 15–17%, which is about 3 times lower
than that of conventional ones (42–48%). Notably, the as-prepared
fluorophore@CD@SNPs show observable less cytotoxicity as compared
with their conventional counterparts, probably due to the substantially
decreased leakage of the incorporated fluorophores. Because of prominent
properties and versatile fabrication, the proposed fluorophore@CD@SNPs
not only possess better performances for cell-imaging but are competent
for ratiometric sensing of pH value at living cell using (indicator-reference)
integrative silica NPs
Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System
Pressure sensors
with high sensitivity, a wide linear range, and
a quick response time are critical for building an intelligent disease
diagnosis system that directly detects and recognizes pulse signals
for medical and health applications. However, conventional pressure
sensors have limited sensitivity and nonideal response ranges. We
proposed a multichannel flexible pulse perception array based on polyimide/multiwalled
carbon nanotube–polydimethylsiloxane nanocomposite/polyimide
(PI/MPN/PI) sandwich-structure pressure sensor that can be applied
for remote disease diagnosis. Furthermore, we established a mechanical
model at the molecular level and guided the preparation of MPN. At
the structural level, we achieved high sensitivity (35.02 kPa–1) and a broad response range (0–18 kPa) based
on a pyramid-like bilayer microstructure with different upper and
lower surfaces. A 27-channel (3 Ă— 9) high-density sensor array
was integrated at the device level, which can extract the spatial
and temporal distribution information on a pulse. Furthermore, two
intelligent algorithms were developed for extracting six-dimensional
pulse information and automatic pulse recognition (the recognition
rate reaches 97.8%). The results indicate that intelligent disease
diagnosis systems have great potential applications in wearable healthcare
devices