5 research outputs found
Additional file 1: Figure S1. of Effectiveness of multi-drug regimen chemotherapy treatment in osteosarcoma patients: a network meta-analysis of randomized controlled trials
Risk of bias graph of each included study. (EPS 2203 kb
Additional file 5: Table S3. of Effectiveness of multi-drug regimen chemotherapy treatment in osteosarcoma patients: a network meta-analysis of randomized controlled trials
The league table of the network for the overall survival estimates the treatments according to their relative effects for second part. (DOCX 14 kb
Additional file 2: Table S1. of Effectiveness of multi-drug regimen chemotherapy treatment in osteosarcoma patients: a network meta-analysis of randomized controlled trials
The league table of the network for the progression-free survival estimates the treatments according to their relative effects. (DOCX 19 kb
Additional file 4: Table S2. of Effectiveness of multi-drug regimen chemotherapy treatment in osteosarcoma patients: a network meta-analysis of randomized controlled trials
The league table of the network for the overall survival estimates the treatments according to their relative effects for first part. (DOCX 14 kb
Enhanced Antitumor Efficacy of Novel Biomimetic Platelet Membrane-Coated Tetrandrine Nanoparticles in Nonsmall Cell Lung Cancer
Nonsmall cell lung cancer (NSCLC) remains one of the
leading causes
of cancer-related death worldwide, posing a serious threat to global
health. Tetrandrine (Tet) is a small molecule in traditional Chinese
medicine with proven primary efficacy against multiple cancers. Although
previous studies have demonstrated the potential anticancer effects
of Tet on NSCLC, its poor water solubility has limited its further
clinical application. Herein, a novel nanoparticle-based drug delivery
system, platelet membrane (PLTM)-coated Tet-loaded polycaprolactone-b-poly(ethylene glycol)-b-polycaprolactone
nanoparticles (PTeNPs), is proposed to increase the potency of Tet
against NSCLC. First, tetrandrine nanoparticles (TeNPs) are created
using an emulsion solvent evaporation method, and biomimetic nanoparticles
(PTeNPs) are prepared by coating the nanoparticles with PLTMs. When
coated with PLTMs, PTeNPs are considerably less phagocytized by macrophages
than Tet and TeNPs. In addition, compared with Tet and TeNPs, PTeNPs
can significantly inhibit the growth and invasion of NSCLC both in
vitro and in vivo. With reliable biosafety, this drug delivery system
provides a new method of sustained release and efficient anticancer
effects against NSCLC, facilitating the incorporation of Tet in modern
nanotechnology