24 research outputs found
Thermodynamic properties and viscosities of CaO-SiO2-MgO-Al2O3 slags
In this work, the effects of AlO, basicity, and MgO/AlO ratio on the heat capacity, enthalpy change, and viscosity of CaO-SiO-MgO-AlO slags at 1773 K, 1823 K, and 1873 K (1500 °C, 1550 °C, and 1600 °C) were investigated. The heat capacity of the slag increased with increasing AlO, basicity, and MgO/AlO ratio in the experimental temperature range. The enthalpy change increased with increasing AlO content and MgO/AlO ratio, and decreasing basicity. Under the fixed heat quantity of the slag, the addition of AlO would result in a decrease of slag temperature and increase of slag viscosity. The effect of decreasing temperature on the viscosity was more significant than increasing AlO content. Increases of slag basicity led to the increased slag temperature and the decreased viscosity which was due to the increased slag temperature. The viscosity change rate with different temperatures was more pronounced than that of different slag compositions. The change of the slag temperature at fixed heat quantity would be opposite due to different expressions of MgO/AlO ratio. In addition, when the heat decrement of the slag was fixed, the slag temperature rose first with the increase of MgO/AlO ratio and then decreased, while the viscosity decreased gradually. The viscosity fluctuation caused by different heat decrements reduced as well with increasing MgO/AlO ratio
Thermodynamic properties and viscosities of CaO-SiO2-MgO-Al2O3 slags
In this work, the effects of AlO, basicity, and MgO/AlO ratio on the heat capacity, enthalpy change, and viscosity of CaO-SiO-MgO-AlO slags at 1773 K, 1823 K, and 1873 K (1500 °C, 1550 °C, and 1600 °C) were investigated. The heat capacity of the slag increased with increasing AlO, basicity, and MgO/AlO ratio in the experimental temperature range. The enthalpy change increased with increasing AlO content and MgO/AlO ratio, and decreasing basicity. Under the fixed heat quantity of the slag, the addition of AlO would result in a decrease of slag temperature and increase of slag viscosity. The effect of decreasing temperature on the viscosity was more significant than increasing AlO content. Increases of slag basicity led to the increased slag temperature and the decreased viscosity which was due to the increased slag temperature. The viscosity change rate with different temperatures was more pronounced than that of different slag compositions. The change of the slag temperature at fixed heat quantity would be opposite due to different expressions of MgO/AlO ratio. In addition, when the heat decrement of the slag was fixed, the slag temperature rose first with the increase of MgO/AlO ratio and then decreased, while the viscosity decreased gradually. The viscosity fluctuation caused by different heat decrements reduced as well with increasing MgO/AlO ratio
Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives
Targeted protein degradation (TPD), a promising therapeutic
strategy
in drug discovery, has great potential to regulate the endogenous
degradation of undruggable targets with small molecules. As vital
resources that provide diverse structural templates for drug discovery,
natural products (NPs) are a rising and robust arsenal for the development
of therapeutic TPD. The first proof-of-concept study of proteolysis-targeting
chimeras (PROTACs) was a natural polyketide ovalicin-derived degrader;
since then, NPs have shown great potential to promote TPD technology.
The use of NP-inspired targeted protein degraders has been confirmed
to be a promising strategy to treat many human conditions, including
cancer, inflammation, and nonalcoholic fatty liver disease. Nevertheless,
the development of NP-inspired degraders is challenging, and the field
is currently in its infancy. In this review, we summarize the bioactivities
and mechanisms of NP-inspired degraders and discuss the associated
challenges and future opportunities in this field
A Cellulose-Type Carrier for Intimate Coupling Photocatalysis and Biodegradation
Intimate coupling photocatalysis and biodegradation treatment technology is an emerging technology in the treatment of refractory organic matter, and the carrier plays an important role in this technology. In this paper, sugarcane cellulose was used as the basic skeleton, absorbent cotton was used as a reinforcing agent, anhydrous sodium sulfate was used as a pore-forming agent to prepare a cellulose porous support with good photocatalytic performance, and nano-TiO2 was loaded onto it by a low-temperature bonding method. The results showed that the optimal preparation conditions of cellulose carriers were: cellulose mass fraction 1.0%; absorbent cotton 0.6 g; and Na2SO4 60 g. The SEM, EDS and XPS characterization further indicated that the nano-TiO2 was uniformly loaded onto the cellulose support. The degradation experiments of Rhodamine B showed that the nano-TiO2-loaded composite supports had good photocatalytic performance. The degradation rate of 1,2,4-trichlorobenzene was more than 92% after 6 cycles, and the experiment of adhering a large number of microorganisms on the carriers before and after the reaction showed that the cellulose-based carriers obtained the required photocatalytic performance and stability, which is a good cellulose porous carrier
The investigation of electrical properties and microstructure of ZnO-doped Ba0.9Sr0.1TiO3 ceramics
Ba0.9Sr0.1TiO3 ceramics with or without ZnO have been prepared by traditional solid state reaction method. The XRD analysis showed that the doped Zn2+ ions diffused into the BST crystal lattice, resulting in the variation of dielectric properties. Especially the dielectric constant at Curie point decreased with doping ZnO content when it is lower than 0.5mol%. Due to the promotion of sintering, doping ZnO can enhance the density of ceramics but increase grain size. However, ZnO is a kind of semiconductor and can lead to the decrease in electrical breakdown strength value
The effects of TMDD-PA concentration on roughness of Si 〈1 1 0〉 and etching rate ratio of Si 〈1 1 0〉/〈1 1 1〉 in alkaline KOH solution
Study on Degradation of 1,2,4-TrCB by Sugarcane Cellulose-TiO<sub>2</sub> Carrier in an Intimate Coupling of Photocatalysis and Biodegradation System
1,2,4 trichlorobenzene (1,2,4-TrCB) is a persistent organic pollutant with chemical stability, biological toxicity, and durability, which has a significant adverse impact on the ecological environment and human health. In order to solve the pollution problem, bagasse cellulose is used as the basic framework and nano TiO2 is used as the photocatalyst to prepare composite carriers with excellent performance. Based on this, an intimate coupling of photocatalysis and biodegradation (ICPB) system combining photocatalysis and microorganisms is constructed. We use the combined technology for the first time to deal with the pollution problem of 1,2,4-TrCB. The biofilm in the composite carrier can decompose the photocatalytic products so that the removal rate of 1,2,4-TrCB is 68.01%, which is 14.81% higher than those of biodegradation or photocatalysis alone, and the mineralization rate is 50.30%, which is 11.50% higher than that of photocatalysis alone. The degradation pathways and mechanisms of 1,2,4-TrCB are explored, which provide a theoretical basis and potential application for the efficient degradation of 1,2,4-TrCB and other refractory organics by the ICPB system
Preparation and Photocatalytic Properties of a Bagasse Cellulose-Supported Nano-TiO2 Photocatalytic-Coupled Microbial Carrier
Intimate coupling of photocatalysis and biodegradation (ICPB) has shown promise in removing unwanted organic compounds from water. In this study, bagasse cellulose titanium dioxide composite carrier (SBC-TiO2) was prepared by low-temperature foaming methods. The optimum preparation conditions, material characterization and photocatalytic performance of the composite carrier were then explored. By conducting a single factor test, we found that bagasse cellulose with a mass fraction of 4%, a polyvinyl alcohol solution (PVA) with a mass fraction of 5% and 20 g of a pore-forming agent were optimum conditions for the composite carrier. Under these conditions, good wet density, porosity, water absorption and retention could be realized. Scanning electron microscopy (SEM) results showed that the composite carrier exhibited good biologic adhesion. X-ray spectroscopy (EDS) results confirmed the successful incorporation of nano-TiO2 dioxide into the composite carrier. When the mass concentration of methylene blue (MB) was 10 mg L−1 at 200 mL, 2 g of the composite carrier was added and the initial pH value of the reaction was maintained at 6, the catalytic effect was best under these conditions and the degradation rate reached 78.91% after 6 h. The method of preparing the composite carrier can aid in the degradation of hard-to-degrade organic compounds via ICPB. These results provide a solid platform for technical research and development in the field of wastewater treatment
Data in support of the discovery of alternative splicing variants of quail LEPR and the evolutionary conservation of qLEPRl by nucleotide and amino acid sequences alignment
Leptin receptor (LEPR) belongs to the class I cytokine receptor superfamily which share common structural features and signal transduction pathways. Although multiple LEPR isoforms, which are derived from one gene, were identified in mammals, they were rarely found in avian except the long LEPR. Four alternative splicing variants of quail LEPR (qLEPR) had been cloned and sequenced for the first time (Wang et al., 2015Â [1]). To define patterns of the four splicing variants (qLEPRl, qLEPR-a, qLEPR-b and qLEPR-c) and locate the conserved regions of qLEPRl, this data article provides nucleotide sequence alignment of qLEPR and amino acid sequence alignment of representative vertebrate LEPR. The detailed analysis was shown in [1]. Keywords: Quail LEPR, Alternative splicing, Evolutionary conservation, Sequence alignmen