(1S,4S)-2-(2,4-Difluoro­phen­yl)-5-[(4-methyl­phen­yl)sulfon­yl]-2,5-diaza­bicyclo­[2.2.1]hepta­ne

In the title mol­ecule, C18H18F2N2O2S, the two benzene rings, which are oriented in opposite directions with respect to the rigid 2,5-diaza­bicyclo­[2.2.1]heptane core, form a dihedral angle of 17.2 (1)°. Weak inter­molecular C—H⋯O, C—H⋯F and C—H⋯N contacts consolidate the crystal packing

6-Oxo-5-[(trifluoro­meth­yl)sulfon­yl]-1,2,4a,5,6,11b-hexa­hydro-1,3-dioxolo[4,5-j]phenanthridin-2-yl benzoate

In the title compound, C22H16F3NO7S, the two benzene rings are almost perpendicular, the dihedral angle between their mean planes being 87.1 (1)°. The terminal O atom of the benzoate moiety is disordered over two positions with site occupancies of 0.244 (15) and 0.756 (15). The crystal structure is stablized by two types of weak inter­molecular C—H⋯O hydrogen bonds

Lateral distribution calculation of multi-I beam composite curved bridge with slip effect

This paper presents a modified rigid cross beam method to study the lateral distribution of multi-I beam composite curved bridge with slip effect. First, the effective stiffness expression of single composite curved beam with slip effect were established and calculated by the FEM. Secondly, the lateral load distribution of multi-I beam composite curved bridge is obtained by substituting the effective stiffness of the main composite curved beam into the rigid cross beam method. Finally, The FEM numerical examples show that this method can accurately describe the load distribution characteristics of multi-I beam composite curved bridge with slip effect

Direct and inverse problems on free vibration analysis of cracked non-uniform beams carrying spring-mass systems by finite element method

This paper presents an analytical approach to investigate the free vibration analysis of cracked non-uniform beam carrying spring-mass systems by finite element method and illustrates a valid and reliable damage identification method which using hybrid neural genetic technique. Firstly, based on the finite element method, the dynamic characteristics of non-uniform cracked beam carrying spring-mass systems are obtained. Then, the first five frequencies are used as input parameters by combining genetic algorithm with neural network to identify the damage. Finally, Numerical simulations of direct and inverse problems of non-uniform cracked beams carrying a spring-mass system are carried out

Stabilization diagrams to distinguish physical modes and spurious modes for structural parameter identification

A novel clustering stabilization diagram combined with self adaptive differential evolution algorithm is proposed to identify the modal parameters of civil engineering structures. Compared with the traditional stabilization diagram, the clustering diagram has drawn more attention because it can distinguish physical and spurious modes due to its automatic performance. In this paper, a self adaptive differential evolution algorithm is proposed to optimize the initial clustering centers so as to improve the clustering stabilization diagram. Moreover, this paper presents a new idea that the modal assurance criterion (MAC) composed of mode shapes is selected as the Y-axis to replace the model orders or damping ratios in existing stabilization diagrams. The results of a benchmark test of bridge Z24 and the numerical simulation of a continuous beam and a cable-stayed bridge demonstrate the advantages of the proposed approaches and the reliability of detecting the modal parameters

Melatonin protects against ovarian damage by inhibiting autophagy in granulosa cells in rats

Objectives: This study sought to further verify the protective mechanism of Melatonin (MT) against ovarian damage through animal model experiments and to lay a theoretical and experimental foundation for exploring new approaches for ovarian damage treatment. Method: The wet weight and ovarian index of rat ovaries were weighted, and the morphology of ovarian tissues and the number of follicles in the pathological sections of collected ovarian tissues were recorded. And the serum sex hormone levels, the key proteins of the autophagy pathway (PI3K, AKT, mTOR, LC3II, LC3I, and Agt5) in rat ovarian tissues, as well as the viability and mortality of ovarian granulosa cells in each group were measured by ELISA, western blotting, CCK8 kit and LDH kit, respectively. Results: The results showed that MT increased ovarian weight and improved the ovarian index in ovarian damage rats. Also, MT could improve autophagy-induced ovarian tissue injury, increase the number of primordial follicles, primary follicles, and sinus follicles, and decrease the number of atretic follicles. Furthermore, MT upregulated serum AMH, INH-B, and E2 levels downregulated serum FSH and LH levels in ovarian damage rats and activated the PI3K/AKT/mTOR signaling pathway. Besides, MT inhibited autophagic apoptosis of ovarian granulosa cells and repressed the expression of key proteins in the autophagic pathway and reduced the expression levels of Agt5 and LC3II/I. Conclusions: MT inhibits granulosa cell autophagy by activating the PI3K/Akt/mTOR signaling pathway, thereby exerting a protective effect against ovarian damage

(2,4-Difluoro­phen­yl)[1-(1H-1,2,4-triazol-1-yl)cyclo­prop­yl]methanone

The asymmetric unit of the title compound, C12H9F2N3O, contains two independent mol­ecules (A and B) in which the benzene and cyclo­propane rings form dihedral angles of 33.0 (1) and 29.7 (1)°, respectively. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link alternating A and B mol­ecules into chains along [010]

A Study on Public Adoption of Robo-Taxis in China

Autonomous vehicles (AVs) have been reported to improve road safety, reduce traffic congestion, and increase urban mobility. However, the high price of AVs is currently a challenge for most consumers. Robo-taxi services, with ride-sharing services and AVs, are regarded as a good approach to solving this problem. As some companies have started testing Robo-taxis on the actual road, it has become important to investigate public adoption of Robo-taxi services before they are more widely introduced to the market. This study aims to explain and predict users’ acceptance of Robo-taxis by extending the Technology Acceptance Model by including the construct of social influence. Data were collected from an online survey in China and analyzed using linear regression models. The results indicate that perceived usefulness, perceived ease of use, and social influence have significant positive correlations with people’s behavior intentions to use Robo-taxis. Perceived ease of use further has an indirect effect on intention to use via perceived usefulness. The results of this study can serve as good references for policymakers, operators, and future transport researchers. Document type: Articl

Density Matrix Approach to Local Hilbert Space Reduction

We present a density matrix approach for treating systems with a large or infinite number of degrees of freedom per site with exact diagonalization or the density matrix renormalization group. The method is demonstrated on the 1D Holstein model of electrons coupled to Einstein phonons. In this system, two or three optimized phonon modes per site give results as accurate as with 10-100 bare phonon levels per site.Comment: 4 pages, 4 figure