Characteristics of studies investigating human papillomavirus (HPV) 16 infection in oral squamous cell carcinoma (OSCC) and control samples.

<p>Pos: Positive; Neg: Negative.</p

Forest plot of human papillomavirus 16 prevalence in oral squamous cell carcinoma and control samples.

<p>OSCC: oral squamous cell carcinoma.</p

Funnel plot of the included studies of oral squamous cell carcinoma risk in HPV16 infection.

<p>Funnel plot of the included studies of oral squamous cell carcinoma risk in HPV16 infection.</p

Forest plot of human papillomavirus prevalence in oral squamous cell carcinoma and control samples.

<p>OSCC: oral squamous cell carcinoma.</p

Funnel plot of the included studies of oral squamous cell carcinoma risk in HPV infection.

<p>Funnel plot of the included studies of oral squamous cell carcinoma risk in HPV infection.</p

The Clinical Value of Huangqi Injection in the Treatment of Leucopenia: A Meta-Analysis of Clinical Controlled Trials

<div><p>Background</p><p>Huangqi injection is derived from Astragalus membranaceus root. In China, recent reports of Huangqi injection for the treatment of leucopenia have emerged. However, a systematic review of these reports has not been performed. Thus, we conducted a meta-analysis of clinical controlled trials to assess the clinical value of Huangqi injection in the treatment of leucopenia. </p> <p>Methods</p><p>We searched the Chinese Biomedical Literature Database (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Full-text Database (VIP), as well as PubMed and EMBASE to collect the data about trials of Huangqi injection for treating leucopenia. A meta-analysis was performed using RevMan 5.2 software. </p> <p>Results</p><p>A total of 13 studies involving 841 patients were included in this study. The overall study quality was lower according to the Jadad scale. The meta-analysis showed that experimentally treated patients experienced greater therapeutic efficacy and lower white blood cell counts than control groups treated with Western medicine (<i>P</i> < 0.05). No publication bias was evident, according to Egger’s test. </p> <p>Conclusions</p><p>The validity of this meta-analysis was limited by the overall poor quality of the included studies. Huangqi injection may have potential clinical value in the treatment of leucopenia, but confirmation with rigorously well-designed multi-center trials is needed.</p> </div

Effectiveness of Huangqi injection for the treatment of leucopenia.

<p>Events: the numbers of the effective cases.</p

Funnel plots based on data of overall effectiveness.

<p>Funnel plots based on data of overall effectiveness.</p

Flow diagram of literature retrieval.

<p>Flow diagram of literature retrieval.</p