1 research outputs found
Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications
Uniformly controlling a large number
of metal nanostructures with
a plasmonically enhanced signal to generate quantitative optical signals
and the widespread use of these structures for surface-enhanced Raman
scattering (SERS)-based biosensing and bioimaging applications are
of paramount importance but are extremely challenging. Here, we report
a highly controllable, facile selective-interdiffusive dealloying
chemistry for synthesizing the dealloyed intra-nanogap particles (DIPs)
with a ∼2 nm intragap in a high yield (∼95%) without
the need for an interlayer. The SERS signals from DIPs are highly
quantitative and polarization-independent with polarized laser sources.
Remarkably, all the analyzed particles displayed the SERS enhancement
factors (EFs) of ≥1.1 × 10<sup>8</sup> with a very narrow
distribution of EFs. Finally, we show that DIPs can be used as ultrasensitive
SERS-based DNA detection probes for detecting 10 aM to 1 pM target
concentrations and highly robust, quantitative real-time cell imaging
probes for long-term imaging with low laser power and short exposure
time