Effect of body mass index on diabetogenesis factors at a fixed fasting plasma glucose level

<div><p>Aim</p><p>The present study evaluated the relative influence of body mass index (BMI) on insulin resistance (IR), first-phase insulin secretion (FPIS), second-phase insulin secretion (SPIS), and glucose effectiveness (GE) at a fixed fasting plasma glucose level in an older ethnic Chinese population.</p><p>Methods</p><p>In total, 265 individuals aged 60 years with a fasting plasma glucose level of 5.56 mmol/L were enrolled. Participants had BMIs of 20.0–34.2 kg/m². IR, FPIS, SPIS, and GE were estimated using our previously developed equations. Pearson correlation analysis was conducted to assess the correlations between the four diabetogenesis factors and BMI. A general linear model was used to determine the differences in the percentage of change among the four factor slopes against BMI.</p><p>Results</p><p>Significant correlations were observed between BMI and FPIS, SPIS, IR, and GE in both women and men, which were higher than those reported previously. In men, BMI had the most profound effect on SPIS, followed by IR, FPIS, and GE, whereas in women, the order was slightly different: IR, followed by FPIS, SPIS, and GE. Significant differences were observed among all these slopes, except for the slopes between FPIS and SPIS in women (p = 0.856) and IR and FPIS in men (p = 0.258).</p><p>Conclusions</p><p>The contribution of obesity to all diabetes factors, except GE, was higher than that reported previously. BMI had the most profound effect on insulin secretion in men and on IR in women in this 60-year-old cohort, suggesting that lifestyle modifications for obesity reduction in women remain the most important method for improving glucose metabolism and preventing future type 2 diabetes mellitus.</p></div

sj-pdf-1-imr-10.1177_03000605221115161 - Supplemental material for Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population

Supplemental material, sj-pdf-1-imr-10.1177_03000605221115161 for Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population by Tzong-Yow Wu, En-Chih Liao, Yen-Lin Chen, Yung-Feng Lin, Shu-Hsiang Liu, Hua-Ching Lin, Yi-Chou Chiu, Chung-Ze Wu, Jiunn-Diann Lin, Dee Pei and Chun-Hsien Hsu in Journal of International Medical Research</p

Demographic characteristics and indices of glucose metabolism in all participants with or without metabolic syndrome.

<p>Demographic characteristics and indices of glucose metabolism in all participants with or without metabolic syndrome.</p

Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of women.

<p>Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of women.</p

Comparison of the demographic characteristics and indices of glucose metabolism in different groups.

<p>Comparison of the demographic characteristics and indices of glucose metabolism in different groups.</p

Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of men.

<p>Slopes of insulin resistance, first-phase and second-phase insulin secretions, and glucose effectiveness against the body mass indices of men.</p

The correlations between the body mass index and diabetes factors.

<p>The correlations between the body mass index and diabetes factors.</p