Energy Efficient Transmission over Space Shift Keying Modulated MIMO Channels

Energy-efficient communication using a class of spatial modulation (SM) that encodes the source information entirely in the antenna indices is considered in this paper. The energy-efficient modulation design is formulated as a convex optimization problem, where minimum achievable average symbol power consumption is derived with rate, performance, and hardware constraints. The theoretical result bounds any modulation scheme of this class, and encompasses the existing space shift keying (SSK), generalized SSK (GSSK), and Hamming code-aided SSK (HSSK) schemes as special cases. The theoretical optimum is achieved by the proposed practical energy-efficient HSSK (EE-HSSK) scheme that incorporates a novel use of the Hamming code and Huffman code techniques in the alphabet and bit-mapping designs. Experimental studies demonstrate that EE-HSSK significantly outperforms existing schemes in achieving near-optimal energy efficiency. An analytical exposition of key properties of the existing GSSK (including SSK) modulation that motivates a fundamental consideration for the proposed energy-efficient modulation design is also provided

Liquid biopsy genotyping in lung cancer: ready for clinical utility?

Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its potential to detect driver oncogenes such as epidermal growth factor receptor (EGFR) mutants in lung cancer. This technology is advancing rapidly and is being incorporated into numerous EGFR tyrosine kinase inhibitor (EGFR-TKI) development programs. It appears ready for integration into clinical care. Recent studies have demonstrated that biological fluids such as saliva and urine can also be used for detecting EGFR mutant DNA through application other user-friendly techniques. This review focuses on the clinical application of liquid biopsies to lung cancer genotyping, including EGFR and other targets of genotype-directed therapy and compares multiple platforms used for liquid biopsy

The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer.

The advances in targeted therapies for lung cancer are based on the evaluation of specific gene mutations especially the epidermal growth factor receptor (EGFR). The assays largely depend on the acquisition of tumor tissue via biopsy before the initiation of therapy or after the onset of acquired resistance. However, the limitations of tissue biopsy including tumor heterogeneity and insufficient tissues for molecular testing are impotent clinical obstacles for mutation analysis and lung cancer treatment. Due to the invasive procedure of tissue biopsy and the progressive development of drug-resistant EGFR mutations, the effective initial detection and continuous monitoring of EGFR mutations are still unmet requirements. Circulating tumor DNA (ctDNA) detection is a promising biomarker for noninvasive assessment of cancer burden. Recent advancement of sensitive techniques in detecting EGFR mutations using ctDNA enables a broad range of clinical applications, including early detection of disease, prediction of treatment responses, and disease progression. This review not only introduces the biology and clinical implementations of ctDNA but also includes the updating information of recent advancement of techniques for detecting EGFR mutation using ctDNA in lung cancer

Common wave behavior for mergers and acquisitions in OECD countries? a unique analysis using new Markov switching panel model approach

This paper investigates whether or not there is co-waved merger and acquisition (M&A) activity in 26 OECD countries. We apply the Markov Switching model to panel data (MSP hereafter), an approach which has not previously been attempted. Two distinct regimes are recognized in emerge from M&A data: the wave merger regime and normal merger regime. Our MSP captures the co-wave pattern of the sample countries and has a much better fit than either the univariate Markov Switching model or the conventional linear panel model.