Preoperative Diagnosis of Fallopian Tube Carcinoma by Transvaginal Sonography, MRI and CA125

AbstractPrimary fallopian tube carcinoma is the least common of the gynecological malignancies and rarely diagnosed preoperatively. We report the case of a 70-year-old woman with primary tubal carcinoma, which was diagnosed preoperatively on the basis of elevated CA125 and characteristic features found by transvaginal sonography, transvaginal color flow imaging and magnetic resonance imaging. Transvaginal ultrasonography showed a sausage-shaped solid mass alongside the right ovary. Transvaginal color Doppler imaging revealed characteristically low impedance vascular flow within the solid components. A pathohistological study confirmed the diagnosis of fallopian tube carcinoma

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

The role of nonhistone chromosomal proteins of human lymphocytes in cell cycle regulation.

The role of nonhistone chromosomal proteins of human lymphocytes in cell cycle regulation

Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery

Solvent recovery is an important process in the pharmaceutical industry, but organic solvent nanofiltration membranes operate under high pressures. Here the authors demonstrate organic solvent forward osmosis — an alternative process that does not require application of external pressure and may prove to be economically favorable

Hydrophobic Perfluoropolyether-Coated Thin-Film Composite Membranes for Organic Solvent Nanofiltration

10.1021/acsapm.8b00171ACS Applied Polymer Materials13472-48

Organic solvent nanofiltration (OSN) membranes made from plasma grafting of polyethylene glycol on cross-linked polyimide ultrafiltration substrates

Journal of Membrane Scienc

Large retroperitoneal extraskeletal Ewing’s sarcoma with renal pedicle invasion: a case report

Abstract Background Extraskeletal Ewing’s sarcoma (EES) is a rare malignant tumor primarily found in children and young adults. Localized disease can present with nonspecific symptoms such as local mass, regional pain, and increased skin temperature. More severe cases may present with systemic symptoms such as malaise, weakness, fever, anemia, and weight loss. Among these lesions, retroperitoneal sarcomas are relatively uncommon and difficult to diagnose. Since they are usually asymptomatic until large enough to compress or invade the surrounding tissues, most are already advanced at first detection. Traditionally, the treatment of choice is complete surgical resection, sometimes combined with postoperative radiotherapy and chemotherapy. We report a case of EES with left renal artery invasion in the left retroperitoneal cavity successfully treated with transarterial embolization and surgery. Case presentation A 57-year-old woman with a negative family history of cancer presented at our Urology Department with a large left retroperitoneal tumor found by magnetic resonance imaging during the health exam. Physical examination showed a soft abdomen and no palpable mass or tenderness. Imaging studies showed that the tumor covered the entire left renal pedicle, but the left kidney, left adrenal gland, and pancreas appeared tumor free. Since the tumor tightly covered the entire renal pedicle, tumor excision with radical nephrectomy was advised. The patient underwent transarterial embolization of the left renal artery with 10 mg of Gelfoam pieces daily before surgical excision. Tumor excision and left radical nephrectomy were uneventful the day after embolization. Post-operatively, the patient recovered well and was discharged on day 10. The final histopathological analysis showed a round blue cell tumor consistent with an Ewing sarcoma, and the surgical margins were tumor free. Conclusions Retroperitoneal malignancies are rare but usually severe conditions. Our case report showed that retroperitoneal EES with renal artery invasion could be treated safely with transarterial embolization and surgery