49 research outputs found

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    Get PDF
    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

    Tailoring pore size and pore size distribution of kidney dialysis hollow fiber membranes via dual-bath coagulation approach

    No full text
    10.1016/j.memsci.2006.12.036Journal of Membrane Science2901-2153-163JMES

    Customization of distributed systems using COM

    No full text

    The investigation of irregular inner skin morphology of hollow fiber membranes at high-speed spinning and the solutions to overcome it

    No full text
    10.1016/j.memsci.2006.05.044Journal of Membrane Science2821-2383-392JMES
    corecore