Design and Strategic Synthesis of Some β-Carboline-Based Novel Natural Products of Biological Importance

β-Carboline compounds and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. Many bioactive β-carboline-based natural products have been found to be an important source of drugs and drug leads. β-Carboline has major players in natural products chemistry, which plays an important role in drug discovery. β-Carboline represents the core unit of several natural products, alkaloids, and bioactive compounds. The unusual and complex molecular architectures of natural products pose significant challenges to organic chemists and are a source of inspiration for the development of new organic reactions and innovative synthetic strategies. However, in many cases, β-carboline natural products are isolated in only minute quantities, and their constant supply from natural sources is problematic or virtually impossible. In addition, chemoselective derivatization of natural products themselves is usually quite difficult because of their sensitive and elaborate molecular structures, and access to their structural analogs is severely restricted in many cases. Since chemical synthesis is expected to be the only way to overcome these shortcomings, β-carboline natural products are rewarding synthetic targets for organic chemists. This chapter assimilates the reports pertaining to the synthetic applications of some β-carbolines for the synthesis of substituted and fused β-carbolines

CPCP violation in b→sℓℓb \to s \ell \ell: a model independent analysis

We perform a model-independent global fit to all germane and updated $b \to s \ell \ell$ ($\ell=e,\,\mu$) data assuming new physics couplings to be complex. Under the approximation that new physics universally affects muon and electron sectors and that either one or two related operators contribute at a time, we identify scenarios which provide a good fit to the data. It turns out that the favored scenarios remain the same as obtained for the real fit. Further, the magnitude of complex couplings can be as large as that of their real counterparts and these are reflected in the predictions of the direct $CP$ asymmetry, $A_{\rm CP}$, in $B \to (K,\, K^*) \mu^+ \mu^-$ along with a number of angular $CP$ asymmetries, $A_i$, in $B^0 \to K^{*0} \mu^+ \mu^-$ decay. The sensitivities of these observables to various solutions are different in the low and high-$q^2$ bins. We also determine observables which can serve as unique identifier for a particular new physics solution. Moreover, we examine correlations between $A_{\rm CP}$ and several $A_i$ observables. A precise measurement of $A_{\rm CP}$ and $A_i$ observables can not only confirm the existence of additional weak phases but can also enable unique determination of Lorentz structure of possible new physics in $b \to s \mu^+ \mu^-$ transition.Comment: 15 pages, 4 figures; updated results in view of December 2022 LHCb measurement

Microwave assisted synthesis of 2,4-diaryl-2,3-dihydro-1H-1,5-benzodiazepines on solventless inorganic solid support and their antibacterial activities

The chemical reactivity of α,β-unsaturated carbonyl system of synthesised substituted chalcones have been utilized for the synthesis of variously substituted benzodiazepines by the reaction of O-phenylenediamine (OPDA).In the present investigation we have carried out the reactionunder both conventional method and microwave assisted organic synthesis (MAOS) technique in presence of basic alumina / silica gel. The results of this procedure when compared to conventional method, demonstrate the versatility of the solid phase microwave assisted process resulting remarkable rate enhancement and dramatic reduction in reaction time, with better yield. The structure of compounds are supported by spectral and analytical data. The structure-activity relationship of synthesized compounds have also been studied

Effectiveness of Laparoscopic Ovarian Drilling (LOD) on restoration of menstrual cycles, ovulation and pregnancy in clomiphene citrate resistant women with PCOS

Background: Anovulatory infertility is present in 75% of patients with polycystic ovarian syndrome (PCOS), in addition to oligomenorrhoea and signs and symptoms of hyperandrogenism. This study was performed to evaluate the role of laparoscopic ovarian drilling (LOD) on ovulation, restoring menstrual cycles and pregnancy in clomiphene resistant women with PCOS.Methods: This prospective cohort study included 50 women who were diagnosed with PCOS and anovulatory infertility. These patients had already tried Clomiphene citrate for conception and did not ovulate, underwent LOD between 1st September 2009 until February 2011 in the Department of Gynecology and Obstetrics, at the Panna Dhay Mahila Chikitasalya, Udaipur. The major outcome measures include spontaneous ovulation, menstrual regularity after LOD and pregnancy rates.Results: Among 50 patients 33 (66%) started to menstruate regularly and 60% ovulated spontaneously, of them 24 (48%) conceived.Conclusions: Women with PCOS respond favourably to LOD

COMPARATIVE EFFICACY OF CLOSED AND OPEN KINETIC CHAIN EXERCISES ON DEVELOPMENT OF EXPLOSIVE STRENGTH IN LOWER EXTREMITY

The purpose of the study is to compare the efficacy of closed and open kinetic chain exercises on development of explosive strength in lower extremity and to determine which mode of training resulted in the greatest performance enhancement. The case study incorporated randomly a total of seventy five college level players of different games, each aged between 19 to 24 years. The total seventy five players were randomly divided into equal three groups. Among these groups, two different groups were gone through closed chain kinetic and open chain kinetic exercises respectively and one group kept as control group. Progressive weight training thrice a week for 7 weeks scheduled. Necessary data was collected by administering standing broad jump performance prior to training and at the completion of the training period. Statistical technique Analysis of covariance test was applied to compare the efficacy between closed chain and open chain kinetic exercise at 0.05 level of significance, while significant changes were seen in the open kinetic chain group and close chain kinetic group. The closed kinetic chain group improved in .16 meters which was significantly more than the .08 meters seen in the open kinetic chain group. The result reveals close chain kinetic exercise mode of training resulted in the greatest strength development in lower extremity.  Article visualizations

Microwave assisted synthesis of 3,5–diaryl-6-carbethoxy cyclohex-2-en-1-ones on solvent less inorganic solid supportand their antibacterial activities

A variety of 3,5–diaryl–6-carbethoxy cyclohex-2-en-1-ones derivatives (4a-g) were synthesized by the reaction of ethylacetoacetate with substituted chalcones in conventional(acetone & anhy. K 2CO3) and microwave assisted solution phase (acetone & anhy. K 2CO3) and dry media (basic Al 2O3/piperidine). From the comparative study wehave concluded that efficient dry media synthesis of 3,5–diaryl–6-carbethoxy cyclohex-2-en-1-ones under microwave irradiation can be carried out in domestic microwave oven with enhanced reaction rates and improved yields.The structure of compounds are supported by spectral and analytical data. The structure activity relationship of synthesized compounds have also been studied

Microwave assisted synthesis of 3,5–diaryl-6-carbethoxy cyclohex-2-en-1-ones on solvent less inorganic solid supportand their antibacterial activities

A variety of 3,5–diaryl–6-carbethoxy cyclohex-2-en-1-ones derivatives (4a-g) were synthesized by the reaction of ethylacetoacetate with substituted chalcones in conventional(acetone & anhy. K 2CO3) and microwave assisted solution phase (acetone & anhy. K 2CO3) and dry media (basic Al 2O3/piperidine). From the comparative study wehave concluded that efficient dry media synthesis of 3,5–diaryl–6-carbethoxy cyclohex-2-en-1-ones under microwave irradiation can be carried out in domestic microwave oven with enhanced reaction rates and improved yields.The structure of compounds are supported by spectral and analytical data. The structure activity relationship of synthesized compounds have also been studied

A COMPARATIVE STUDY OF KAPAL BHATI AND MEDOHARA ARKA IN THE MANAGEMENT OF STHAULYA (OBESITY)

Obesity is a blessing of the Modern age of Machines and Materialism. The impact of modern civilization has absolutely changed our life styles. Most of the peoples are forced to live a sedentary life. Obesity is a type of disease, which invites many major & minor manifestations. Ayurveda has described one of such disorder as Sthaulya. The parallel in western medicine to this order is “Obesity. It is clinically prove that both Yoga and Ayurveda are mutually supportive and offer many ways to prevent and heal various disorders as well as cleanse and rejuvenate the body. Kapal Bhati is reliable to control the Sthaulya. Medohara Arka is known to exert several beneficial physiological effects including the anti-obesitic influence.Study Design: 90 patients, randomly divided into three groups with 30 patients in each group. In Group A, Kapal bhati was administered twice a day for 15 minutes in morning and evening on empty stomach for 45 days. In Group B, Medohara arka was administered in 30 ml dose with Madhu anupana twice a day for 45 days and in Group C, both Kapal Bhati and Medohara arka was administered as mentioned above.Results & Conclusion: Marked Improvement was not observed in any of the groups. Moderate Improvement was observed in 6.66 % patients in Group A and 3.33% in Group C. Mild Improvement was observed in 80% patients in Group C and 60% patients in Group A & 53.33% in Group B. No improvement was observed as 36.66% in Group B, 33.33% in Group A and 16.66% in Group C. Thus, it can be concluded that the Kapal Bhati along with Medohara Arka is effective in the management of Sthaulya as it is safe, cost effective and free from any side effects

AYURVEDIC APPROACH IN ORAL HEALTH & HYGIENE: A REVIEW

Oral diseases continue to be a major health problem world-wide with the incidence of oral cancer and other disorders are on the rise in developing countries. Oral health also reflects the body health. For prevention and the treatment of oral diseases, modern medicine has had only limited success. There is a global need for safe and effective alternative prevention and treatment. Ayurveda is good alternative for that and may lead to the development of novel preventive or therapeutic strategies for oral health. This 5000-year-old system of medicine not only recommends treatments with specific herbs and minerals to cure various oral diseases but also recommends some daily use therapeutic procedures for the prevention of and maintenance of oral health.Recently, there is renewed interest in use of Ayurvedic drugs for oral health. Various Ayurvedic herbs and natural products have been used for their pharmacological applications viz. antiulcer, wound healing, anti-inflammatory, antimicrobial and antioxidant properties and have been proven to be safe and effective for oral disease and hygiene including various therapeutic Ayurvedic procedures. Scientific validations of the Ayurveda oral health practices could justify their incorporation into modern oral care. In this paper, an attempt has been made to scientific evidence based review various therapeutic procedures for the prevention and maintenance of oral health and hygiene mentioned in Ayurveda.

Torsion of gravid horn of bicornuate uterus: a rare case report

Torsion uterus is a rare complication of the third trimester of pregnancy. Etiological factors associated are myoma, mullerian anomalies, ovarian cyst, sudden change of lie of fetus and trauma. We report a rare case of levorotation of the gravid horn of bicornuate uterus leading to severe abruption and intrauterine death of the fetus. The case was managed by an emergency laparotomy with excision of the atonic gravid horn of bicornuate uterus. This is the third such case reported in the English literature as per our knowledge