Enhanced γ-Glutamyltranspeptidase Imaging That Unravels the Glioma Recurrence in Post-radio/Chemotherapy Mixtures for Precise Pathology via Enzyme-Triggered Fluorescent Probe

Accurate pathological diagnosis of gliomas recurrence is crucial for the optimal management and prognosis prediction. The study here unravels that our newly developed γ-glutamyltranspeptidase (GGT) fluorescence probe (Figure 1A) imaging in twenty recurrent glioma tissues selectively recognizes the most malignant portion from treatment responsive tissues induced by radio/chemo-therapy (Figure 1B). The overexpression of GGT in recurrent gliomas and low level in radiation necrosis were validated by western blot analysis and immunohistochemistry. Furthermore, the ki-67 index evaluation demonstrated the significant increase of malignancy, aided by the GGT-responsive fluorescent probe to screen out the right specimen through fast enhanced imaging of enzyme activity. Importantly, our GGT-targeting probe can be used for accurate determination of pathologic evaluation of tumor malignancy, and eventually for guiding the following management in patients with recurrent gliomas

Vertical Interface Induced Dielectric Relaxation in Nanocomposite (BaTiO3)1-x:(Sm2O3)x Thin Films

Vertical interfaces in vertically aligned nanocomposite thin films have been approved to be an effective method to manipulate functionalities. However, several challenges with regard to the understanding on the physical process underlying the manipulation still remain. In this work, because of the ordered interfaces and large interfacial area, heteroepitaxial (BaTiO(3))(1-x):(Sm(2)O(3))(x) thin films have been fabricated and used as a model system to investigate the relationship between vertical interfaces and dielectric properties. Due to a relatively large strain generated at the interfaces, vertical interfaces between BaTiO(3) and Sm(2)O(3) are revealed to become the sinks to attract oxygen vacancies. The movement of oxygen vacancies is confined at the interfaces and hampered by the misfit dislocations, which contributed to a relaxation behavior in (BaTiO(3))(1-x):(Sm(2)O(3))(x) thin films. This work represents an approach to further understand that how interfaces influence on dielectric properties in oxide thin films

Oxygen-vacancy-mediated dielectric property in perovskite Eu0.5Ba0.5TiO3-δ epitaxial thin films

Dielectric relaxation in ABO3 perovskite oxides can result from many different charge carrier-related phenomena. Despite a strong understanding of dielectric relaxations, a detailed investigation of the relationship between the content of oxygen vacancies (VO) and dielectric relaxation has not been performed in perovskite oxide films. In this work, we report a systematic investigation of the influence of the VO concentration on the dielectric relaxation of Eu0.5Ba0.5TiO3-δ epitaxial thin films. Nuclear resonance backscattering spectrometry was used to directly measure the oxygen concentration in Eu0.5Ba0.5TiO3-δ films. We found that dipolar defects created by VO interact with the off-centered Ti ions, which results in the dielectric relaxation in Eu0.5Ba0.5TiO3-δ films. Activation energy gradually increases with the increasing content of VO. The present work significantly extends our understanding of relaxation properties in oxide films

An Attention-Averaging-Based Compression Algorithm for Real-Time Transmission of Ship Data via Beidou Navigation System

The real-time transmission of ship status data from vessels to shore is crucial for live status monitoring and guidance. Traditional reliance on expensive maritime satellite systems for this purpose is being reconsidered with the emergence of the global short message communication service offered by the BeiDou-3 navigation satellite system. While this system presents a more cost-effective solution, its bandwidth is notably insufficient for handling real-time ship status data. This inadequacy necessitates the compression of such data. Therefore, this paper introduces an algorithm tailored for real-time compression of sequential ship status data. The algorithm is engineered to ensure both accuracy and the preservation of valid data range integrity. Our methodology integrates quantization, predictive coding employing an attention-averaging-based predictor, and arithmetic coding. This combined approach facilitates the transmission of succinct messages through the BeiDou Navigation System, enabling the live monitoring of ocean-going vessels. Experimental trials conducted with authentic data obtained from ship monitoring systems validate the efficiency of our approach. The achieved compression rates closely approximate theoretical minimum values. Consequently, this method exhibits substantial promise for the real-time transmission of parameters across various systems

Fish Scale for Wearable, Self-Powered TENG

Flexible and wearable devices are attracting more and more attention. Herein, we propose a self-powered triboelectric nanogenerator based on the triboelectric effect of fish scales. As the pressure on the nanogenerator increases, the output voltage of the triboelectric nanogenerator increases. The nanogenerator can output a voltage of 7.4 V and a short-circuit current of 0.18 μA under a pressure of 50 N. The triboelectric effect of fish scales was argued to be related to the lamellar structure composed of collagen fiber bundles. The nanogenerator prepared by fish scales can sensitively perceive human activities such as walking, finger tapping, and elbow bending. Moreover, fish scales are a biomass material with good biocompatibility with the body. The fish-scale nanogenerator is a kind of flexible, wearable, and self-powered triboelectric nanogenerator showing great prospects in healthcare and body information monitoring

Are oil spills enhancing outbreaks of red tides in the Chinese coastal waters from 1973 to 2017?

Between 1973 and 2017, evidences of red tide outbreaks and oil spill accidents in the Chinese coastal waters were collected. Statistical analysis and multiple regression models were used to determine the relationship between the red tide and the oil spill. Major findings reveal that (1) the frequency of red tides positively correlates to the number of oil spills and the volume of oil spilled as well; (2) the higher percentage of small spills (< 7 tonnes) are more likely to enhance the outbreaks of red tides; (3) both EI Nino and storm events do not show any relationship with red tides; and (4) more severe oil spill with penalty recorded implies a higher possibility to trigger the red tide afterwards. Therefore, oil spill contingency management focusing on small oil spills and mitigating their spill effect by physical measures could be of benefit to decrease the frequency of red tides significantly. For example, it is suggested to carry out physical combat instead of chemical dispersants to remove the spilled small oil in the shallow coastal areas for reducing the outbreak risk of red tides after the oil spill

Pseudo-relaxor behavior in 0.35La(2)O(3)-0.65Nb(2)O(5) glass prepared by aerodynamic levitation method

0.35La(2)O(3)-0.65Nb(2)O(5) glasses were prepared by aerodynamic levitation method. The dielectric properties of the sample were investigated as a function of temperature (30-700 degrees C) in the frequency range from 100 Hz to 1 MHz. The glasses show a temperature and frequency-independent dielectric constant of 40 below 200 degrees C. A relaxor-like behavior was observed above 200 degrees C, which was found to be composed of two relaxations with the activation energy of 1.32 eV and 1.3 eV for the low- and high temperature relaxations, respectively. Impedance analysis reveals that the low-temperature relaxation is a conduction relaxation associated with hopping motion of oxygen ions and the high-temperature one is a Maxwell-Wagner relaxation associated with phase boundary. The relaxor-like behavior is attributed to the combining effect of both relaxations. (C) d2016 Elsevier Ltd. All rights reserved

Coupling Analysis on Microstructure and Residual Stress in Selective Laser Melting (SLM) with Varying Key Process Parameters

With the application of Selective Laser Melting (SLM) technology becoming more and more widespread, it is important to note the process parameters that have a very important effect on the forming quality. Key process parameters such as laser power (P), scan speed (s), and scanning strategy (μ) were investigated by determining the correlation between the microstructure and residual stress in this paper. A total of 10 group 316L specimens were fabricated using SLM for comprehensive analysis. The results show that the key process parameters directly affect the morphology and size of the molten pool in the SLM deposition, and the big molten pool width has a direct effect on the larger grain size and crystal orientation distribution. In addition, the larger grain size and misorientation angle also affect the size of the residual stress. Therefore, better additive manufacturing grain crystallization can be obtained by reasonably adjusting the process parameter combinations. The transfer energy density can synthesize the influence of four key process parameters (P, v, the hatching distance (δ), and the layer thickness (h)). In this study, it is proposed that the accepted energy density will reflect the influence of five key process parameters, including the scanning trajectory (μ), which can reflect the comprehensive effect of process parameters more accurately