Effect of ruthenium red (RuR) on hypotonicity-induced [Ca²⁺]_i rise.

<p>(A-B), Representative traces showing the effect of RuR (20 µM) on hypotonicity-induced [Ca²⁺]_i rise in IMR90-iPSC-ECs (A) and HGPS-iPSC-ECs (B). (C and D), Summarized data showing the effect of RuR on transient phase (C) and sustained phase (D) of hypotonicity-induced [Ca²⁺]_i rise. n  =  6–7 independent experiments, 5–10 cells per experiment. ^**<i>p</i><0.01 or ^##<i>p</i><0.01 unpaired <i>t</i>-test compared with corresponding vehicle control.</p

Effect of tranilast on hypotonicity-induced [Ca²⁺]_i rise.

<p>(A-B), Representative traces showing the effect of tranilast (100 µM) on hypotonicity-induced [Ca²⁺]_i rise in IMR90-iPSC-ECs (A) and HGPS-iPSC-ECs (B). (C and D), Summarized data showing the effect of tranilast on transient phase (C) and sustained phase (D) of hypotonicity-induced [Ca²⁺]_i rise. n  =  6–7 independent experiments, 5–10 cells per experiment. ^**<i>p</i><0.01 unpaired <i>t</i>-test compared with vehicle control.</p