Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells

Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells

Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells

Ilelic Acids A and B, Two Unusual Triterpenes with a Seven-Membered Ring from <i>Ilex latifolia</i>

Two unusual triterpenes, ilelic acids A (<b>1</b>) and B (<b>2</b>), together with their biosynthetic related compounds ilelic acids C (<b>3</b>) and D (<b>4</b>) were isolated from the leaves of <i>Ilex latifolia</i>. Their structures with absolute configurations were elucidated by spectroscopic analysis and modified Mosher’s method. The plausible biogenetic pathway of <b>1</b> and <b>2</b> is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 and MDA-MB-231 cells

Ilelic Acids A and B, Two Unusual Triterpenes with a Seven-Membered Ring from <i>Ilex latifolia</i>

Two unusual triterpenes, ilelic acids A (<b>1</b>) and B (<b>2</b>), together with their biosynthetic related compounds ilelic acids C (<b>3</b>) and D (<b>4</b>) were isolated from the leaves of <i>Ilex latifolia</i>. Their structures with absolute configurations were elucidated by spectroscopic analysis and modified Mosher’s method. The plausible biogenetic pathway of <b>1</b> and <b>2</b> is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 and MDA-MB-231 cells