raw data of the study-Retrospective Study using Magnetic Resonance Imaging (MRI) to Measure Depths of Acupuncture Points in Neck and Shoulder Region

This document contains the raw data of 394 subjects including sex,BMI and measured depth of each point in the study: Retrospective Study using Magnetic Resonance Imaging (MRI) to Measure Depths of Acupuncture Points in Neck and Shoulder Region

Hematoma Shape, Hematoma Size, Glasgow Coma Scale Score and ICH Score: Which Predicts the 30-Day Mortality Better for Intracerebral Hematoma?

<div><p>Purpose</p><p>To investigate the performance of hematoma shape, hematoma size, Glasgow coma scale (GCS) score, and intracerebral hematoma (ICH) score in predicting the 30-day mortality for ICH patients. To examine the influence of the estimation error of hematoma size on the prediction of 30-day mortality.</p><p>Materials and Methods</p><p>This retrospective study, approved by a local institutional review board with written informed consent waived, recruited 106 patients diagnosed as ICH by non-enhanced computed tomography study. The hemorrhagic shape, hematoma size measured by computer-assisted volumetric analysis (CAVA) and estimated by ABC/2 formula, ICH score and GCS score was examined. The predicting performance of 30-day mortality of the aforementioned variables was evaluated. Statistical analysis was performed using Kolmogorov-Smirnov tests, paired t test, nonparametric test, linear regression analysis, and binary logistic regression. The receiver operating characteristics curves were plotted and areas under curve (AUC) were calculated for 30-day mortality. A P value less than 0.05 was considered as statistically significant.</p><p>Results</p><p>The overall 30-day mortality rate was 15.1% of ICH patients. The hematoma shape, hematoma size, ICH score, and GCS score all significantly predict the 30-day mortality for ICH patients, with an AUC of 0.692 (<i>P</i> = 0.0018), 0.715 (<i>P</i> = 0.0008) (by ABC/2) to 0.738 (<i>P</i> = 0.0002) (by CAVA), 0.877 (<i>P</i><0.0001) (by ABC/2) to 0.882 (<i>P</i><0.0001) (by CAVA), and 0.912 (<i>P</i><0.0001), respectively.</p><p>Conclusion</p><p>Our study shows that hematoma shape, hematoma size, ICH scores and GCS score all significantly predict the 30-day mortality in an increasing order of AUC. The effect of overestimation of hematoma size by ABC/2 formula in predicting the 30-day mortality could be remedied by using ICH score.</p></div

Scatter plots of size estimated by ABC/2 formula and size difference versus size measured by CAVA of intracerebral hematomas.

<p>Scatter plots of size estimated by ABC/2 formula and size difference versus size measured by CAVA of intracerebral hematomas.</p

Predictive performance of the variables.

<p>AUC: Area under the receiver operating characteristics curve; Sn: Sensitivity; Sp: Specificity; LR+: positive likelihood ratio; LR-: negative likelihood ratio; GCS: Glasgow coma scale; ICH: intracerebral hematoma; CAVA: computer-assisted volumetric analysis; IVH: intraventricular hemorrhage;</p><p>*Indicates a parameter used in the ICH score <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0102326#pone.0102326-Hemphill1" target="_blank">[8]</a>.</p

Comparison of ROC curves in predicting the 30-day mortality by GCS, ICH scores, ICH size, and ICH shape.

<p>Comparison of ROC curves in predicting the 30-day mortality by GCS, ICH scores, ICH size, and ICH shape.</p

Pairwise comparisons of ROC curves.

<p>ROC: receiver operating characteristics; AUC: Area under the ROC curve; CI: confidence interval; ICH: intracerebral hematoma; CAVA: computer-assisted volumetric analysis; GCS: Glasgow coma scale.</p

Comparisons between regular and irregular intracerebral hematomas.

<p>Note: Data are presented as mean ± standard deviation or numbers (%); INR: international normalized ratio; GCS: Glasgow coma scale; ICH: intracerebral hematoma;</p><p>*Hematoma size is measured by computer-assisted volumetric analysis.</p

Bar chart of 30-day mortality versus ICH Score.

<p>There is no apparent difference between the ABC/2 and CAVA methods regarding the 30-day mortality no matter in trend or in each ICH score.</p

Demographic and clinical characteristics of ICH patients.

<p>Note: Data are presented as mean ± standard deviation or numbers (%); BP: blood pressure; GCS: Glasgow coma scale; ICH: intracerebral hematoma; INR: international normalized ratio;</p><p>*Patients are classified into death and survival groups based on the 30-day mortality.</p

Axial brain CT images demonstrating regular hematoma shapes (A–C) and irregular hematoma shapes (D–I).

<p>Regular hematoma shape implies roundish (A) or ovoid (B & C) shape with smooth margin, while irregular hematoma shape refers to pleomorphic contour (D–F), separated adjacent hematomas (G & H) and multicentric hematomas (I).</p