Cantharimide and Its Derivatives from the Blister Beetle <i>Mylabris phalerata</i> Palla

Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (<b>1</b>–<b>3</b>), five 1,2-dimethyl cantharimide-type derivatives (<b>4</b>, <b>5</b>, <b>7</b>–<b>9</b>), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (<b>10</b>–<b>12</b>), together with seven known cantharimides (<b>6</b>, <b>13</b>–<b>18</b>), were isolated from <i>Mylabis phalerata</i> Palla. The planar structures and absolute configurations of compounds <b>1</b>–<b>14</b> were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds <b>6</b>, <b>15</b>, <b>16</b>, and <b>18</b> were found to be potent inhibitors of HBV virus, with IC₅₀ values of 62, 42, 58, and 19 μM

Cantharimide and Its Derivatives from the Blister Beetle <i>Mylabris phalerata</i> Palla

Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (<b>1</b>–<b>3</b>), five 1,2-dimethyl cantharimide-type derivatives (<b>4</b>, <b>5</b>, <b>7</b>–<b>9</b>), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (<b>10</b>–<b>12</b>), together with seven known cantharimides (<b>6</b>, <b>13</b>–<b>18</b>), were isolated from <i>Mylabis phalerata</i> Palla. The planar structures and absolute configurations of compounds <b>1</b>–<b>14</b> were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds <b>6</b>, <b>15</b>, <b>16</b>, and <b>18</b> were found to be potent inhibitors of HBV virus, with IC₅₀ values of 62, 42, 58, and 19 μM