6 research outputs found
Novel Solution- and Solid-Phase Strategies for the Parallel and Combinatorial Synthesis of Small-Molecular-Weight Compound Libraries
In this account dedicated to '100 years Roche' in CHIMIA, we present some of our strategies towards the synthesis of interesting novel amino-acid-derived building blocks; multigeneration synthesis of thiazole libraries in solution; a novel solid-phase approach towards highly substituted pyrimidines using a novel safety-catch linker principle and a multidirectional cleavage procedure; a versatile solid-phase synthesis of quinazolones taking advantage of the Staudinger phosphorylimine chemistry combined with a novel cyclization and cleavage strategy, and finally a novel solid-phase diketopiperazine synthesis combining the Ugi four-component reaction with a final ring-forming cleavage step
Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia
Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida albicans, also showed high
affinity for the human enzyme (hOSC). Here the evaluation process of different scaffolds is outlined for two representative series, the phenyl substituted benzo[d]isothiazoles and the aminocyclohexanes. The most promising compounds derived from the latter series were further profiled
in vivo and showed promising properties with respect to modulation of lipid parameters
SUMO User Conference 2019
SUMO2019:Editor's Preface
This volume contains the papers presented at the SUMO Conference 2019 Simulating Connected Urban Mobility. The conference was held in Berlin from 13-15 May 2019. The goal of the conference was to present new results in the field of mobility simulation and modelling using traffic tools and data which are open available.There were 32 submissions. Each submission was reviewed by at least 2 program committee members. The committee decided to accept 22 papers.
Traffic simulations have a high value for traffic research studies. New traffic strategies can be tested and evaluated in advance with little costs. For realistic simulation results a complex traffic simulation framework is needed. One microscopic traffic simulation for this purpose is the open source tool Eclipse SUMO (Simulation of open mobility) which is available since 2001. SUMO provides a wide range of transport planning and modelling applications.
The major topic of the 7th SUMO conference is the simulation of connected vehicles. This volume contains articles about simulator coupling, connected and automated Vehicles. Furthermore, the journal includes also papers about new algorithms for traffic light systems and new applications for the simulation of other traffic modes or reinforcement learning strategies.
We would like to thank EasyChair for the conference support and its helpfull conference management tool.
Laura Bieker-Walz
Melanie Weber
Robert Hilbrich
Michael Behrisch
July 24, 2019
Berli