Complexes of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 with zinc(II), cadmium(II), nickel(II), and cobalt(II) cations

Reaction of the potassium salt of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 (HL) with ZnII, CdII, NiII and CoII in aqueous EtOH leads to complexes of common formula M(L-S,S′)2 (ML2). Complexes were investigated by IR, UV-Vis, 1H and 31P{1H} NMR spectroscopy and microanalysis The structure of complex NiL2 was investigated by single crystal X-ray diffraction analysis. The nickel(II) ion has a squre-planar environment, S4, with two anionic ligands involving 1,5-S,S′-coordination mode. The ligands are bound in a trans configuration. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Modification of the anticestodal drug 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide with a view to improve its biological effect

Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. © 2014 Pleiades Publishing, Ltd

Modification of the anticestodal drug 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide with a view to improve its biological effect

Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. © 2014 Pleiades Publishing, Ltd

Modification of the anticestodal drug 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide with a view to improve its biological effect

Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. © 2014 Pleiades Publishing, Ltd

Modification of the anticestodal drug 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxybenzamide with a view to improve its biological effect

Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. © 2014 Pleiades Publishing, Ltd

Complexes of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 with zinc(II), cadmium(II), nickel(II), and cobalt(II) cations

Reaction of the potassium salt of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 (HL) with ZnII, CdII, NiII and CoII in aqueous EtOH leads to complexes of common formula M(L-S,S′)2 (ML2). Complexes were investigated by IR, UV-Vis, 1H and 31P{1H} NMR spectroscopy and microanalysis The structure of complex NiL2 was investigated by single crystal X-ray diffraction analysis. The nickel(II) ion has a squre-planar environment, S4, with two anionic ligands involving 1,5-S,S′-coordination mode. The ligands are bound in a trans configuration. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Complexes of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 with zinc(II), cadmium(II), nickel(II), and cobalt(II) cations

Reaction of the potassium salt of N-thiophosphorylthiourea tBuNHC(S)NHP(S)(OiPr)2 (HL) with ZnII, CdII, NiII and CoII in aqueous EtOH leads to complexes of common formula M(L-S,S′)2 (ML2). Complexes were investigated by IR, UV-Vis, 1H and 31P{1H} NMR spectroscopy and microanalysis The structure of complex NiL2 was investigated by single crystal X-ray diffraction analysis. The nickel(II) ion has a squre-planar environment, S4, with two anionic ligands involving 1,5-S,S′-coordination mode. The ligands are bound in a trans configuration. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Crystal structure of phosphonium carboxylate complexes. the role of the metal coordination geometry, ligand conformation and hydrogen bonding

© the Partner Organisations 2014. A series of new mononuclear and heteronuclear complexes of carboxylate phosphonium betaines with biologically important metals (Zn(ii), Cd(ii), Hg(ii) and Cu(ii)) were obtained in aqueous media at ambient temperature. X-ray single crystal diffraction showed that carboxylate phosphonium betaines exhibit versatile complexation abilities, producing monomeric, dimeric and tetrameric homonuclear and mixed metal complexes. The binding mode was found to change in the series of Zn(ii), Cd(ii) and Hg(ii) complexes with an increase of the cation radius. Water and chlorine atoms, bound to the metal, play an important role in crystal formation. In the case of α- and β-substituted phosphabetaines, the crystallization of various stereoisomers was observed including a rare case of co-crystallization of two diastereomers in one crystal. This journal i

Crystal structure of phosphonium carboxylate complexes. the role of the metal coordination geometry, ligand conformation and hydrogen bonding

© the Partner Organisations 2014. A series of new mononuclear and heteronuclear complexes of carboxylate phosphonium betaines with biologically important metals (Zn(ii), Cd(ii), Hg(ii) and Cu(ii)) were obtained in aqueous media at ambient temperature. X-ray single crystal diffraction showed that carboxylate phosphonium betaines exhibit versatile complexation abilities, producing monomeric, dimeric and tetrameric homonuclear and mixed metal complexes. The binding mode was found to change in the series of Zn(ii), Cd(ii) and Hg(ii) complexes with an increase of the cation radius. Water and chlorine atoms, bound to the metal, play an important role in crystal formation. In the case of α- and β-substituted phosphabetaines, the crystallization of various stereoisomers was observed including a rare case of co-crystallization of two diastereomers in one crystal. This journal i

La Patrie : journal quotidien, politique, commercial et littéraire

25 février 18671867/02/25 (A27)