1 research outputs found
Allylic C–S Bond Construction through Metal-Free Direct Nitroalkene Sulfonation
A metal-free, open-flask
protocol was developed for the preparation
of allylic sulfones through direct condensation of sodium arylsulfinates
and β,β-disubstituted nitroalkenes. The key step of this
process was the Lewis base-promoted equilibrium between nitroalkenes
and allylic nitro compounds. Through this process, the readily available
conjugated nitroalkenes can be easily converted into allylic nitro
compounds, which contain more reactive Cî—»C bonds toward the
sulfonyl radical addition. As a result, allylic sulfones were prepared
in excellent yields with a broad substrate scope under mild conditions