Romanian journal of psychoanalysis : = Revue Roumain de Psychanalyse

Course-dependent chemotherapy response of the T-ALL mice. When leukemic cells reached 1-5% in PB, mice received chemotherapy composed of CTX (100 mg/kg) and Ara-C (150 mg/kg) for a consecutive 1, 2, 3 and 4 days, respectively. (A) Median survival days post leukemic cell injection were 29, 39.5, 45 and 71.5 for the leukemia-only, one-day treated, two-day treated and three-day treated group, respectively (n = 6-10). For the four-day treated group, no mice died within the inspecting 90 days (n = 6). (B) Leukemic burden in PB of the four differently treating groups (n = 6). Data showed that longer the therapeutic course, longer the relapse-free period. The day on which leukemic cells showed up again in PB for the one-day, two-day and three-day treated groups were the 8th, 11th and 17th day post therapy, respectively. While for the four-day treated group, no appearance of relapse was detected within the inspecting 90 days. (C) White blood cell count in PB of the four differently treating groups (n = 6). Data showed that longer the therapeutic course, heavier the depression of white blood cells post therapy. (D) Platelet count in PB of the four differently treating groups (n = 6). Data showed that longer the therapeutic course, longer the suppression period of platelet in PB post therapy. All data were presented as meanÂąSEM. Statistical significance as: * p<0.05; ** p<0.01; *** p<0.001