A Study on Trust of E-commerce Market Based on Multi-agents Model

The process of the trust production and transfer is both stochastic and rational. In this article, we analyze the characters of this process in consumer’s social networks, by dividing consumers and merchants into two types: Risk-aversion type and Risk-neutral type for consumers, high-grade and low-grade for merchants respectively. Based on multi-agent NETLogo system, three kinds of virtual social networks are constructed, which are the risk-neutral without institution, risk-aversion without institution, risk-aversion but with good institution. The rules of the production and transfer of trust in consumer-to-consumer and merchant-to-consumers are defined. Based on a series of computational experiments and statistical comparison, we draw a conclusion that the characters of consumers do not change the trend of e-business market scale, but only change the equilibrium value. On the other hand, a risk-aversion with good institutional society can boost market to have a highly upward trend and be self-stable. Consequentially, this article indirectly proved of the essentials for establishing the institution-based trust

1,1′-(Butane-1,4-di­yl)bis­[2-(pyridin-2-yl)-1H-benzimidazole]

The complete mol­ecule of the title compound, C28H24N6, is generated by inversion symmetry with the inversion centre located at the mid-point of the central C–C bond of the butanediyl unit. The benzimidazole and pyridine rings are almost coplanar, the dihedral angle between their mean planes being 6.86 (11)°

The chaperone activity of trigger factor is distinct from its isomerase activity during co-expression with adenylate kinase in Escherichia coli

AbstractTo investigate the molecular chaperone function of trigger factor (TF) and its relationship with isomerase activity in vivo, the assisted folding of adenylate kinase (AK) by TF in Escherichia coli was examined by measuring the amounts of soluble AK produced during co-expression. When the mutant of chicken AK, P17G, is expressed in plasmid pBVAK, 95% of the protein is found in inclusion bodies. Co-expression of AK with TF was achieved using a plasmid pBVAT that allowed expression of TF and AK in the same plasmid under separate control. Co-expression with TF resulted in an increase in the amount of soluble AK, with a higher increase when TF was expressed at higher levels in the cell. Co-expression of AK with the two TF mutants, Y221G and F233Y, in which peptidyl-prolyl cis/trans isomerase activity was 1% of wild-type, gave the same results as wild-type TF. This provides in vivo evidence that the molecular chaperone activity of TF is distinct from its isomerase activity

Quantitative trait locus (QTL) mapping for 100-kernel weight of maize (Zea mays L.) under different nitrogen regimes

100-kernel weight (KW) is one of the most important agronomic traits in maize (Zea mays L.), related to yield. To realize its genetic basis, in this study, a recombinant inbred line (RIL) population derived from the cross between Mo17 and Huangzao4 was used for quantitative trait locus (QTL) mapping for KW under high and low nitrogen (N) regimes. As a result, five QTLs were identified on chromosomes 3, 4, 7 and 9, of which three were detected under both N environments, while the other two QTLs were respectively detected under high and low N regimes. These QTLs could explain phenotypic variance rom 4.47 to 14.47%. Due to additive effects, the three QTLs from Mo17, including two on chromosome 3 and one on chromosome 4, could increase KW from 0.64 to 1.01 g, while the other two from Huangzao4 on chromosomes 7 and 9 could decrease KW from 0.62 to 1.07 g. These results are beneficial for understanding the genetic basis of KW and developing the markers linked with KW for marker-assisted selection breeding in maize.Key words: Maize (Zea mays L.), 100-kernel weight, quantitative trait locus (QTL), recombinant inbred line (RIL), nitrogen regime

Tectonic controls on block rotation and sheeted sill emplacement in the Xigaze Ophiolite (Tibet): the construction mode of slow-spreading and ultraslow-spreading oceanic crusts

Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 22(3), (2021): e2020GC009297, https://doi.org/10.1029/2020GC009297.The internal structure of oceanic crusts is not well understood due to the limitation of deep drilling. However, that of ophiolites, i.e., on-land ancient analogs of oceanic lithosphere, could be precisely mapped and measured. The Xigaze ophiolite in Tibet has been regarded as “peculiar”, due to the sheeted sill complex in its upper crust, and non-sheeted diabase sills/dikes crosscutting its mantle and lower crust, which are geometrically different from the primarily vertical sheeted dike complex. Based on extensive field observations, here we present petrological and geochemical data for the Xigaze ophiolite to decipher the origin of sheeted sill complex and its implications for the construction of oceanic crusts. Diabases in the Xigaze ophiolite could be subdivided into sheeted sills, Group 1 non-sheeted dikes, and Group 2 non-sheeted sills, based on their orientations. These diabases cut other lithologies, and hence belong to the latest-stage products. Based on petrological, geochemical, and structural data, we highlight the important role of detachment fault in the generation of sheeted and non-sheeted sills. During the formation of oceanic crust, large block exhumation, multi-stage rotations, and foundering are argued here as key mechanisms for the generation of Xigaze sheeted and non-sheeted dikes/sills, all of which are in the evolution of detachment fault systems. These processes are also not uncommon for asymmetrical segments at modern slow-spreading and ultraslow-spreading ridges, but are rare at symmetrical segments. Due to the evolution of detachment fault, the internal structures of (ultra)slow-spreading ridges are more complex than those at fast-spreading ridges.This study was financially supported by the National Natural Science Foundation of China (42025201 and 41802062), Key Research Program of Frontier Sciences from CAS (QYZDB-SSW-DQC032), Major Research project on Tethys Geodynamic System from NSFC (91755000), and Open Fund Project of State Key Laboratory of Lithospheric Evolution (201707).2021-07-2

Case report: Amisulpride therapy induced reversible elevation of creatine kinase-MB and bradycardia in schizophrenia

IntroductionSchizophrenia is regarded as one of the most severe, disabling, and costly mental illnesses. Hence, early effective prevention and treatment are critical to the prognosis of patients. Amisulpride, a first-line atypical antipsychotic medication that acts as a blocker of the D2 and D3 dopamine receptors, is used in varying doses for the treatment of both positive and negative symptoms of schizophrenia. Reversible amisulpride-induced elevation of the myocardial enzyme spectrum with bradycardia is a rare condition.Case presentationWe report a 26-year-old patient diagnosed with first-episode schizophrenia. This patient was treated with amisulpride (400 mg/d), but no clinical benefits were obtained. Meanwhile, amisulpride caused elevation of the myocardial enzyme spectrum with asymptomatic bradycardia. After stopping the medication, these parameters normalized.ConclusionWe described a rare side reaction of amisulpride. Psychiatrists should take this side effect seriously in the clinical setting. The mechanism of this adverse reaction warrants further investigation and debate. When this side effect occurs during treatment, reducing the dosage of amisulpride and subsequently discontinuing medication, along with monitoring the electrocardiogram and serum myocardial enzymes, may be the most appropriate treatment protocol

Tree of Life Based on Genome Context Networks

Efforts in phylogenomics have greatly improved our understanding of the backbone tree of life. However, due to the systematic error in sequence data, a sequence-based phylogenomic approach leads to well-resolved but statistically significant incongruence. Thus, independent test of current phylogenetic knowledge is required. Here, we have devised a distance-based strategy to reconstruct a highly resolved backbone tree of life, on the basis of the genome context networks of 195 fully sequenced representative species. Along with strongly supporting the monophylies of three superkingdoms and most taxonomic sub-divisions, the derived tree also suggests some intriguing results, such as high G+C gram positive origin of Bacteria, classification of Symbiobacterium thermophilum and Alcanivorax borkumensis in Firmicutes. Furthermore, simulation analyses indicate that addition of more gene relationships with high accuracy can greatly improve the resolution of the phylogenetic tree. Our results demonstrate the feasibility of the reconstruction of highly resolved phylogenetic tree with extensible gene networks across all three domains of life. This strategy also implies that the relationships between the genes (gene network) can define what kind of species it is

Precise Measurement of Gravity Variations During a Total Solar Eclipse

The variations of gravity were measured with a high precision LaCoste-Romberg D gravimeter during a total solar eclipse to investigate the effect of solar eclipse on the gravitational field. The observed anomaly $(7.0 \pm 2.7) \times 10^{-8}$ m/s$^2$ during the eclipse implies that there may be a shielding property of gravitation

Increased CD4+CD25+ regulatory T cells correlate with poor short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients

BackgroundThe roles of CD4+CD25+ regulatory T cells (Treg) in chronicity of hepatitis B virus (HBV) infection have been confirmed. We aimed to explore alteration of Treg in patients with HBV-related acute-on-chronic liver failure (ACLF).MethodsThirty-two HBV-related ACLF patients, 44 chronic hepatitis B patients, and 41 healthy controls were recruited. We detected frequencies of peripheral Treg and intrahepatic forkhead winged helix transcription factor (Foxp3)+ cells. Inhibitory activity of Treg was assessed by functional suppression assays. Serum interferon-γ and interleukin-10 were also determined.ResultsPeripheral Treg and intrahepatic Foxp3+ cells were more markedly increased in ACLF than chronic hepatitis B and controls (all p < 0.001), and the Foxp3+ cells located predominantly in the portal areas. The Treg frequency was positively correlated with HBV DNA load, international normalized ratio, model of end stage liver disease score, and serum interleukin-10 level in ACLF patients. Functional assays in vitro demonstrated that ACLF patients exhibited higher suppressive effects of Treg on proliferations of autologous CD4+CD25− T cells than controls. On logistic regression, prolonged international normalized ratio and higher peripheral Treg frequency predicted 30-day survival of ACLF.ConclusionThe patients with HBV-related ACLF exhibit increased amounts of Treg, of which redistribution from periphery to liver seems to modulate liver inflammation. Higher Treg amounts are associated with more severe liver disease in ACLF, and its level in combination with international normalized ratio may assist prediction of short-term outcomes of HBV-related ACLF