3 research outputs found

    Design of a Glass Wall Cleaning Mechanism

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    Cutting down the maintenance cost, reduce the cleaning time and eliminates air pollution are the 3 main objectives set in this project entitle “To Design a glass wall cleaning mechanism”. The challenge here is to design a cleaning mechanism that will clean the outer wall of the glass panel of the Universiti Teknologi PETRONAS academic block while fulfilling the 3 objectives. Thus, a series of criteria were set, and justified, conceptual model to represent the criteria is designed and given verdict before the real product is being design in details. The final product of this project is a detail design of a cleaning mechanism that is supported by a supporting system which will be move across the rooftop of the academic building

    Appui aux travaux conduits sur les systèmes avec semis direct et couvert végétal en Haute Guinée et en Guinée forestière : mission réalisée du 30 juin au 13 juillet 2002

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    Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and 277 additional whole-exome sequences from localized, non-indolent prostate tumours with similar clinical risk profiles, and carried out RNA and methylation analyses in a subset. These tumours had a paucity of clinically actionable single nucleotide variants, unlike those seen in metastatic disease. Rather, a significant proportion of tumours harboured recurrent non-coding aberrations, large-scale genomic rearrangements, and alterations in which an inversion repressed transcription within its boundaries. Local hypermutation events were frequent, and correlated with specific genomic profiles. Numerous molecular aberrations were prognostic for disease recurrence, including several DNA methylation events, and a signature comprised of these aberrations outperformed well-described prognostic biomarkers. We suggest that intensified treatment of genomically aggressive localized prostate cancer may improve cure rates

    Genomic hallmarks of localized, non-indolent prostate cancer

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