Trends in Research about COVID-19 Vaccine Documented through Bibliometric and Visualization Analysis

Due to COVID-19, people’s lives have changed greatly. In accordance with former experience, an efficacious vaccine is the most effective way to curb the pandemic; thus, many researchers have published related publications in the short term. Hence, this study aims at using bibliometric analysis and visualization to document research trends regarding COVID-19 vaccines, and offer some directions and suggestions for future research. Initially, all eligible publications were downloaded from Web of Science on 1 January 2022. Subsequently, some publications published before December 2019 were removed since COVID-19 did not occur before that date. Finally, Microsoft Excel is used for bibliometric analysis to analyze publication date, author, affiliation, country, publication title, publisher, research area, document type, and language, and visualized software (VOSviewer) is used to visualize author, affiliation, country, and keywords. After analyzing a total of 17,392 publications, the results show that the overall research trend was upward. Moreover, the prominent authors, institutions, and countries inclined towards regional cooperation instead of international cooperation. Furthermore, the most popular research areas were immunology and medicine (general and internal). Ultimately, COVID-19, vaccine, and SARS-CoV-2 were the top 3 keywords. In conclusion, this study shows the approximate research trend for COVID-19 vaccine during the completely first two years of the pandemic. The research focuses moved from safety, effectiveness, and immunology at the early stage to the optimal allocation strategies for COVID-19 vaccine, and eventually to public attitudes and acceptance towards COVID-19 vaccination

Synchronous Occurrence of Primary Neoplasms in the Uterus with Squamous Cell Carcinoma of the Cervix and Adenocarcinoma of the Endometrium

SummaryObjectiveSynchronous primary malignant neoplasms of the uterus are uncommon. Patients with synchronous cervical and endometrial cancers are even rarer. We describe a case of cervical squamous cell carcinoma and endometrial endometrioid adenocarcinoma occurring simultaneously in a 47-year-old woman presenting with massive menstrual bleeding. The concept of synchronous primary malignancies of the genital tract is also reviewed in this report.Case ReportA 47-year-old overtly obese female presented with menometrorrhagia of over 6 months' duration. Pelvic examination detected a large cervix but apparently normal externals. Magnetic resonance imaging revealed a mass over the cervical region and endometrial lesions in the uterine cavity. Surgical exploration disclosed a cervical tumor and erosion of the endometrium. The pathologic findings were compatible with synchronous occurrence of primary neoplasms in the uterus with squamous cell carcinoma of the cervix and adenocarcinoma of the endometrium.ConclusionSynchronous genital tract neoplasms are rare but cause more clinical problems than a single neoplasm. It is practical to pay more attention to the differential diagnosis of primary and metastatic tumors. The second primary cancer that occurs in an individual with endometrial cancer may offer an opportunity for early detection. The prognosis for a patient with synchronous gynecologic malignancies does not seem to be worse

Optimum dynamic characteristic control approach for building mass damper design

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142538/1/eqe2995.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142538/2/eqe2995_am.pd

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells. After 24-h treatment with MTH-3, a concentration-dependent decrease in MDA-MB-231 cell viability was observed, and the IC50 value was 5.37±1.22 μM. MTH-3 significantly triggered G2/M phase arrest and apoptosis in MDA-MB-231 cells. Within a 24-h treatment, MTH-3 decreased the CDK1 activity by decreasing CDK1 and cyclin B1 protein levels. MTH-3-induced apoptosis was further confirmed by morphological assessment and Annexin V/PI staining assay. Induction of apoptosis caused by MTH-3 was accompanied by an apparent increase of DR3, DR5 and FADD and, as well as a marked decrease of Bcl-2 and Bcl-xL protein expression. MTH-3 also decreased the protein levels of Ero1, PDI, PERK and calnexin, as well as increased the expression of IRE1α, CHOP and Bip that consequently led to ER stress and MDA-MB-231 cell apoptosis. In addition, MTH-3-treated cells were involved in the autophagic process and cleavage of LC3B was observed. MTH-3 enhanced the protein levels of LC3B, Atg5, Atg7, Atg12, p62 and Beclin-1 in MDA-MB-231 cells. Finally, DNA microarray was carried out to investigate the level changes of gene expression modulated by MTH-3 in MDA-MB-231 cells. Taken together, our results suggest that MTH-3 might be a novel therapeutic agent for the treatment of triple-negative breast cancer in the near future

Sampling Neural Radiance Fields for Refractive Objects

Recently, differentiable volume rendering in neural radiance fields (NeRF) has gained a lot of popularity, and its variants have attained many impressive results. However, existing methods usually assume the scene is a homogeneous volume so that a ray is cast along the straight path. In this work, the scene is instead a heterogeneous volume with a piecewise-constant refractive index, where the path will be curved if it intersects the different refractive indices. For novel view synthesis of refractive objects, our NeRF-based framework aims to optimize the radiance fields of bounded volume and boundary from multi-view posed images with refractive object silhouettes. To tackle this challenging problem, the refractive index of a scene is reconstructed from silhouettes. Given the refractive index, we extend the stratified and hierarchical sampling techniques in NeRF to allow drawing samples along a curved path tracked by the Eikonal equation. The results indicate that our framework outperforms the state-of-the-art method both quantitatively and qualitatively, demonstrating better performance on the perceptual similarity metric and an apparent improvement in the rendering quality on several synthetic and real scenes.Comment: SIGGRAPH Asia 2022 Technical Communications. 4 pages, 4 figures, 1 table. Project: https://alexkeroro86.github.io/SampleNeRFRO/ Code: https://github.com/alexkeroro86/SampleNeRFR

New Insights on 30 Dor B Revealed by High-Quality Multi-wavelength Observations

The supernova remnant (SNR) 30 Dor B is associated with the \ion{H}{2} region ionized by the OB association LH99. The complex interstellar environment has made it difficult to study the physical structure of this SNR. We have used Hubble Space Telescope H$\alpha$ images to identify SNR shocks and deep Chandra X-ray observations to detect faint diffuse emission. We find that 30 Dor B hosts three zones with very different X-ray surface brightnesses and nebular kinematics that are characteristic of SNRs in different interstellar environments and/or evolutionary stages. The ASKAP 888 MHz map of 30 Dor B shows counterparts to all X-ray emission features except the faint halo. The ASKAP 888 MHz and 1420 MHz observations are used to produce a spectral index map, but its interpretation is complicated by the background thermal emission and the pulsar PSR J0537$-$6910's flat spectral index. The stellar population in the vicinity of 30 Dor B indicates a continuous star formation in the past 8--10 Myr. The observed very massive stars in LH99 cannot be coeval with the progenitor of 30 Dor B's pulsar. Adopting the pulsar's spin-down timescale, 5000 yr, as the age of the SNR, the X-ray shell would be expanding at $\sim$4000 km\,s$^{-1}$ and the post-shock temperature would be 1--2 orders of magnitude higher than that indicated by the X-ray spectra. Thus, the bright central region of 30 Dor B and the X-ray shell requires two separate SN events, and the faint diffuse X-ray halo perhaps other older SN events

Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes

<p>Abstract</p> <p>Background</p> <p><it>Arctium lappa </it>(<it>Niubang</it>), a Chinese herbal medicine, is used to treat tissue inflammation. This study investigates the effects of arctigenin (AC), isolated from <it>A. lappa</it>, on anti-CD3/CD28 Ab-stimulated cell proliferation and cytokine gene expression in primary human T lymphocytes.</p> <p>Methods</p> <p>Cell proliferation was determined with enzyme immunoassays and the tritiated thymidine uptake method. Cytokine production and gene expression were analyzed with reverse transcription-polymerase chain reaction.</p> <p>Results</p> <p>AC inhibited primary human T lymphocytes proliferation activated by anti-CD3/CD28 Ab. Cell viability test indicated that the inhibitory effects of AC on primary human T lymphocyte proliferation were not due to direct cytotoxicity. AC suppressed interleukin-2 (IL-2) and interferon-γ (IFN-γ) production in a concentration-dependent manner. Furthermore, AC decreased the IL-2 and IFN-γ gene expression in primary human T lymphocytes induced by anti-CD3/CD28 Ab. Reporter gene analyses revealed that AC decreased NF-AT-mediated reporter gene expression.</p> <p>Conclusion</p> <p>AC inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-γ and NF-AT.</p