328 research outputs found
1-{[3-(2-Chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropan-1-yl]carbonyl}-3-(methylsulfonyl)imidazolidin-2-one
In the title molecule, C13H16ClF3N2O4S, the imidazolidine ring is approximately planar, the largest deviation from this plane being 0.025 (3) Å. The cyclopropane ring forms a dihedral angle of 64.1 (2)° with the imidazolidine ring. In the crystal, C—H⋯O hydrogen bonds are observed
2,7-Dichloro-4-(chloroacetyl)fluorene
There are two molecules in the asymmetric unit of the title compound, C15H9Cl3O. The fluorene rings of the two molecules are both coplanar within 066 (3) Å. In the crystal, C—H⋯O and C—H⋯Cl hydrogen bonds link the molecules into sheets running parallel to (100)
Anti-tumor effect of polysaccharides isolated from Taraxacum mongolicum Hand-Mazz on MCF-7 human breast cancer cells
Purpose: To optimize the extraction conditions for the ultrasound-assisted extraction of polysaccharides from T. mongolicum (PTM) and investigate their anti-tumor effect on human breast cancer MCF-7 cells.Methods: To optimize the extraction conditions of PTM, response surface methodology (RSM) was performed. The effects of extraction temperature, liquid-solid ratio and extraction time on the yield of PTM were investigated using a Box-Behnken design (BBD). The in vitro anti-tumor effect of PTM on MCF-7 cells was investigated by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay, while the mechanism of PTM-induced apoptosis was assessed by evaluating the expressions of p53, Bax and Bcl-2 proteins using western blot analysis. Furthermore, the in vivo anti-tumor effect of PTM on MCF-7 cells was studied in mice.Results: The optimal conditions for the extraction of PTM were as follows: extraction temperature, 58.2°C; liquid-solid ratio, 15 mL/g; and extraction time, 44.12 min. Under these optimal conditions, the yield of PTM was 4.84 ± 0.13 %. PTM showed significant anti-tumor effect on MCF-7 cells in vitro. The expressions of pro-apoptotic proteins, p53 and Bax, were significantly upregulated (p < 0.05), while the expression of anti-apoptotic protein, Bcl-2, was significantly down-regulated (p < 0.05) after treatment with PTM. PTM also showed significant inhibitory effect (p < 0.05) on MCF-7 cells in vivo in a dosedependent manner.Conclusion: RSM is effective in optimizing the extraction conditions of PTM by ultrasonic extraction. PTM possesses significant anti-tumor effect on MCF-7 human breast cancer cells, both in vitro and in vivo.Keywords: Polysaccharides, Taraxacum mongolicum, Human breast cancer, MCF-7 cells, Apoptosis, Box–Behnken design, Response surface methodolog
Effect of Salt Intake on Serum Glucagon-Like Peptide-1 Levels in Normotensive Salt-Sensitive Subjects
2D and 3D Numerical Modeling of Combined Surcharge and Vacuum Preloading with Vertical Drains
Lattice Calculation of the Intrinsic Soft Function and the Collins-Soper Kernel
We calculate the soft function using lattice QCD in the framework of large
momentum effective theory incorporating the one-loop perturbative
contributions. The soft function is a crucial ingredient in the lattice
determination of light cone objects using transverse-momentum-dependent (TMD)
factorization. It consists of a rapidity-independent part called intrinsic soft
function and a rapidity-dependent part called Collins-Soper kernel. We have
adopted appropriate normalization when constructing the pseudo-scalar meson
form factor that is needed in the determination of the intrinsic part and
applied Fierz rearrangement to suppress the higher-twist effects. In the
calculation of CS kernel we consider a CLS ensemble other than the MILC
ensemble used in a previous study. We have also compared the applicability of
determining the CS kernel using quasi TMDWFs and quasi TMDPDFs. As an example,
the determined soft function is used to obtain the physical TMD wave functions
(WFs) of pion and unpolarized iso-vector TMD parton distribution functions
(PDFs) of proton.Comment: 24 pages, 19 figures, published versio
The LAMOST Survey of Background Quasars in the Vicinity of the Andromeda and Triangulum Galaxies -- II. Results from the Commissioning Observations and the Pilot Surveys
We present new quasars discovered in the vicinity of the Andromeda and
Triangulum galaxies with the LAMOST during the 2010 and 2011 observational
seasons. Quasar candidates are selected based on the available SDSS, KPNO 4 m
telescope, XSTPS optical, and WISE near infrared photometric data. We present
509 new quasars discovered in a stripe of ~135 sq. deg from M31 to M33 along
the Giant Stellar Stream in the 2011 pilot survey datasets, and also 17 new
quasars discovered in an area of ~100 sq. deg that covers the central region
and the southeastern halo of M31 in the 2010 commissioning datasets. These 526
new quasars have i magnitudes ranging from 15.5 to 20.0, redshifts from 0.1 to
3.2. They represent a significant increase of the number of identified quasars
in the vicinity of M31 and M33. There are now 26, 62 and 139 known quasars in
this region of the sky with i magnitudes brighter than 17.0, 17.5 and 18.0
respectively, of which 5, 20 and 75 are newly-discovered. These bright quasars
provide an invaluable collection with which to probe the kinematics and
chemistry of the ISM/IGM in the Local Group of galaxies. A total of 93 quasars
are now known with locations within 2.5 deg of M31, of which 73 are newly
discovered. Tens of quasars are now known to be located behind the Giant
Stellar Stream, and hundreds behind the extended halo and its associated
substructures of M31. The much enlarged sample of known quasars in the vicinity
of M31 and M33 can potentially be utilized to construct a perfect astrometric
reference frame to measure the minute PMs of M31 and M33, along with the PMs of
substructures associated with the Local Group of galaxies. Those PMs are some
of the most fundamental properties of the Local Group.Comment: 26 pages, 6 figures, AJ accepte
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