6 research outputs found

    Pruebas diagn贸sticas in vivo en alergia inmediata a penicilina: estudio piloto

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    Antecedentes: La alergia a antibi贸ticos notificada con m谩s frecuencia es la penicilina. La falsa etiqueta de "alergia" a la penicilina afecta negativamente la calidad de vida del paciente y la atenci贸n m茅dica. Objetivo: 聽Determinar la frecuencia de alergia a penicilina y amoxicilina mediante pruebas de exposici贸n in vivo, en pacientes con antecedente de reacci贸n inmediata a esta clase de medicamentos. M茅todos. 聽Estudio observacional, transversal, descriptivo y prolectivo en pacientes entre 12 y 60 a帽os con antecedente de reacci贸n inmediata a penicilina y/o amoxicilina. Se realizaron pruebas cut谩neas por prick e intrade虂rmicas con bencilpeniciloil polilisina y penicilina G, y prueba de reto oral con amoxicilina.聽 La frecuencia de positividad y negatividad en estas pruebas fue calculado con un IC del 95%. Los resultados se analizaron en Epi info 7.2.5.0 Resultados.聽 Se incluyeron 13 pacientes (10 mujeres), con una media de edad 聽de 39 an虄os (DE 12.14) y diagn贸stico predominante de rinitis al茅rgica (61,5%). En 84,6% de casos la 煤ltima reacci贸n adversa a medicamentos ocurri贸 10 a帽os atr谩s y en todos se manifest贸 con urticaria. S贸lo en cinco pacientes (38,4%) se corrobor贸 alergia a penicilina y la reacci贸n adversa m谩s frecuente tras las pruebas in vivo fue prurito (23 %). Conclusiones. La historia cl铆nica por s铆 sola no es suficiente, todos los pacientes con sospecha de alergia a penicilina deben ser evaluados mediante pruebas聽 de exposici贸n in vivo con los determinantes mayores y menores para corroborar o descartar alergia a esta clase farmacol贸gica

    Diagn贸stico de alergia inmediata para penicilina: estudio piloto

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    Objetivos: Confirmar la presencia de alergia a penicilina y amoxicilina mediante pruebas de exposici贸n in vivo, en pacientes que refieren antecedente de reacci贸n inmediata con estos medicamentos. M茅todos: Estudio observacional, transversal, descriptivo y prolectivo. Se incluyeron pacientes entre 12 y 60 a帽os con antecedente de reacci贸n inmediata tras administraci贸n de penicilina y/o amoxicilina. Se realizaron pruebas cut谩neas por prick e intrad茅rmicas con bencilpeniciloil polilisina y penicilina G, as铆 como desaf铆o oral con amoxicilina. Resultados: Se incluyeron 10 pacientes femeninos y 3 masculinos. La edad promedio fue 39 a帽os. En 84,6% de los casos la 煤ltima reacci贸n adversa a medicamentos ocurri贸 10 a帽os atr谩s y en todos los casos se manifest贸 con urticaria. S贸lo en el 38,4% se corrobor贸 alergia a penicilina. La reacci贸n adversa m谩s frecuente, tras las pruebas de exposici贸n in vivo fue prurito en el 23%. Conclusiones: Los pacientes con sospecha de alergia a penicilina se deben evaluar mediante pruebas de exposici贸n in vivo con los determinantes mayores y menores, para corroborar o descartar reacciones al茅rgicas y mejorar las condiciones de tratamiento

    Skin reactivity frequency to aeroallergens in patients with clinical symptoms of allergic disease

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    Background: Allergic diseases diagnosis must be based on adequate allergological anamnesis and an immunological sensitization test; the most sensitive and specific is the skin prick test. Objective: To determine the frequency of skin reactivity to aeroallergens, by age groups, in patients of the Department of Allergy and Clinical Immunology of the Hospital Universitario de Puebla, in Mexico. Methods: A cross-sectional study was conducted that included patients aged 2 to 64 years with symptoms suggestive of allergic disease, in which skin prick tests with aeroallergens were performed; the diagnostic criteria were those of international guidelines. Frequencies, percentages and dispersion measures were calculated. Results: Of 173 patients, 63聽% were females. Mean age was 22.3 years. The frequency of skin reactivity for Quercus sp. was 12.72聽%, for Periplaneta americana, 9.83聽%, for Dermatophagoides farinae, 9.25聽%, for Cynodon dactylon, 8.09聽%, for Blatella germanica, 8.09聽%, for Holcus halepensis, 6.94聽%, for Dermatophagoides pteronyssinus, 6.36聽%, for Schinus molle, 5.78聽%, for Fraxinus uhdei, 5.20聽%, for Lolium perenne, 5.20聽%, for Ambrosia eliator, 5.20聽% and for Artemisa tridentata, 4.62聽%. Conclusion: Although Dermatophagoides are the most frequently reported aeroallergens, the most common aeroallergen in this study was pollen, probably owing to geographical and environmental factors, although this was not observed in the analysis by age groups

    Frequency of skin reactivity to food allergens in allergic patients

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    Background: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10聽%. Objective: To determine the frequency of skin reactivity to food allergens by age groups. Methods: Cross-sectional, descriptive, prolective, observational study. Patients aged from 2 to 64 years with symptoms consistent with allergic disease were included. Skin prick tests were carried out with food allergens. Frequencies and percentages were estimated. Results: One-hundred and ninety-one patients were included, out of which 63.4% were females. Mean age was 22.5 years; 19.3聽% showed positive skin reactivity to at least one food. Distribution by age group was as follows: preschool children 13.5聽%, schoolchildren 24.3聽%, adolescents 2.7聽% and adults 59.5聽%. Diagnoses included allergic rhinitis in 84.3聽%, asthma in 19.4聽%, urticaria in 14.1聽% and atopic dermatitis in 8.4聽%. Positive skin reactivity frequency distribution in descending order was: soybeans with 5.2聽%, peach with 4.7聽%, grapes, orange and apple with 3.6聽%, nuts with 3.1聽%, pineapple, avocado, tomato and tuna with 2.6聽%. Conclusion: The frequency of skin reactivity to food allergens was similar to that reported in the national and Latin American literature, but sensitization to each specific allergen varied for each age group

    Correlation between the Magnitude of Skin Prick Test Reactivity and Pollen-Specific Serum IgE Levels in Patients with Respiratory Allergy

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    Background: For the etiological diagnosis of allergic respiratory diseases skin tests or specific serum IgE determination are used. Objective: To determine the correlation between the extent of reactivity to cutaneous prick tests and the levels of pollen speci c serum IgE in patients with respiratory allergy. Patients and methods: A prolective, descriptive and transversal study was done with patients of both genders, aged 2 to 60 years, who attended for the rst time at the service of Allergy and Clinical Immunology of University Hospital of Puebla, Mexico, with presumptive diagnosis of respiratory allergy. All patients underwent clinical history, skin prick tests with standardized allergenic extracts and quanti cation of pollen speci c serum IgE by chemiluminescence method. We estimated the correlation index r using the statistical method Pearson product-moment correlation coef cient; a value r equal to or higher than 0.70 was con- sidered a signi cant relationship or a high correlation. Results: Nine-one patients were included, of whom 58.2% were female. The diagnoses were: allergic rhinitis (79.1%), asthma and allergic rhinitis (16.5%) and only asthma (4.4%). Only signi cant correlation was found in patients with allergic rhinitis for Rumex crispus (r = 0.702) and in patients with asthma and rhinitis for Ambrosia tri da (r = 1). Conclusion: Only for Rumex crispus and Ambrosia tri da, the skin prick tests or the determination of speci c serum IgE levels are comparable diagnostic methods of allergic respiratory diseases

    Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort

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