Adenosquamous carcinoma of the pancreas: a case report

Adenosquamous carcinoma of the pancreas is a rare variant of pancreatic exocrine carcinoma. We report a case of 70 year old man who came to our hospital with abdominal pain, anorexia and jaundice. Imaging of the abdomen showed a mass in the region of the head of the pancreas. Histological evaluation of the pancreatic tumor showed an adenosquamous carcinoma which was extensively infiltrative with perineural invasion, involvement of peripancreatic lymph nodes and all the thickness of the duodenum wall. The tumor exhibited a biphasic malignant growth identified as well to moderate differentiated adenocarcinoma and well to poorly differentiated squamous cell carcinoma

Correlation of Histological type, Grade and Results of IHC and SISH regarding Cerb2-HER2/neu Amplification

<p><i>Breast cancer is one of the most common causes of death worldwide. The increasing incidence of breast cancer and its associated mortality highlights the need for new diagnostic procedures and immunohistochemical techniques improving the therapeutic management, especially the targeted treatment. To highlight and assess the expression of oncogene HER2, regarding to the results of Immunohistochemistry (IHC) scoring 2+ and Silver DNA in Situ Hybridization (SISH) technique and identify breast cancer type, special histological types, grade, and the correlation regarding to histological type, grade, and other biomarkers such as estrogen and progesterone receptors, and Ki-67.</i></p&gt

Merkel cell carcinoma of the upper extremity: Case report and an update

Abstract Background Merkel cell carcinoma is a rare but aggressive cutaneous primary small cell carcinoma. It is commonly seen in elderly affecting the head, neck, and extremities. Macroscopically may be difficult to distinguish MCC from other small cells neoplasms especially oat cell carcinoma of the lung. Case presentation It is presented a case report concerning a 72 years old male with a MMC on the dorsal aspect of the right wrist. The patient underwent a diagnostic excisional biopsy and after the histological confirmation of the diagnosis a second excision was performed to achieve free margins. No postoperative radiation or adjuvant chemotherapy was given and within 9 years follow up no recurrence was reported. Conclusion Although most cases present as localized disease treatment should be definitive due to high rates of local or systemic recurrence. Treatment includes excision of the lesion, lymphadenectomy, postoperative radiotherapy and chemotherapy depending on the stage of the disease. Even when locoregional control is achieved close surveillance is required due to high rates of relapse.</p