Sensitivity analysis results (LY: life year, QALY: quality adjusted life year, ICER: incremental cost effectiveness ratio); Simulation 1: Exacerbation rate = -46% and Increase QALY = 0.125; Simulation 2: Exacerbation rate = -46% and COPD costs = -10%, Simulation 3: Exacerbation rate = -46% and COPD costs = -10% and Increase QALY = 0.125.

<p>Sensitivity analysis results (LY: life year, QALY: quality adjusted life year, ICER: incremental cost effectiveness ratio); Simulation 1: Exacerbation rate = -46% and Increase QALY = 0.125; Simulation 2: Exacerbation rate = -46% and COPD costs = -10%, Simulation 3: Exacerbation rate = -46% and COPD costs = -10% and Increase QALY = 0.125.</p

Simulation result comparing Respiratory rehabilitation program to usual care (QALY: quality adjusted life year, ICER: incremental cost effectiveness ratio).

<p>Simulation result comparing Respiratory rehabilitation program to usual care (QALY: quality adjusted life year, ICER: incremental cost effectiveness ratio).</p

Decision model.

<p>Four health states (GOLD2 to GOLD4 and death) defining the outcome of a patient with COPD. The arrows indicate the possibility of transition from one state to another. Transition from one state to another, based on GOLD criteria, is unidirectional. GOLD4 patients cannot transit to another stage, and « death » is an absorbing state in which transition to another state is not possible.</p

Acceptability curve.

<p>Percent chances that PR is-cost-effective (as compared to standard care) as a function of the willingness to pay (€/QALY) for it.</p

Probabilistic sensitivity analysis.

<p>Incremental costs (€) of pulmonary rehabilitation intervention as a function of its incremental effectiveness (QALY).</p

characteristics of the population without pulmonary rehabilitation (usual cares) and with pulmonary rehabilitation (PR); ⁺% non smokers/ex-smokers/smokers; ⁺⁺% of patients at least 1 exacerbation per year.

<p>characteristics of the population without pulmonary rehabilitation (usual cares) and with pulmonary rehabilitation (PR); ⁺% non smokers/ex-smokers/smokers; ⁺⁺% of patients at least 1 exacerbation per year.</p