Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection

Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytometry (FC) is usually recommended for the classification and staging of lymphomas in patients with organomegaly and atypical cells in effusions and blood, after the exclusion of other possible diagnoses. FC may also have a place in the initial diagnostic investigation of aggressive lymphoma. Three cases are presented here of highly aggressive lymphomas in young adults, which presented with the clinical picture of fever of unknown origin (FUO) in patients severely ill. All followed a life-threatening clinical course, and two developed the hemophagocytic syndrome (HPS), but microbiological, immunological, and morphological evaluation and immunohistochemistry (IHC) failed to substantiate an early diagnosis. FC was the technique that provided conclusive diagnostic evidence of lymphoma, subsequently verified by IHC. Our experience with these three cases highlights the potential role of FC as an adjunct methodology in the initial assessment of possible highly aggressive lymphoma presenting with the signs and symptoms of life-threatening infection, although the definitive diagnosis should be established by biopsy. In such cases, FC can contribute to the diagnosis of lymphoma, independently of the presence of HPS

Off Label Use of Teriparatide in Spine

Teriparatide belongs to osteo-anabolic compounds and has been used in recent years to treat patients with osteoporosis, with the benefits of increased bone density. Its osteo-anabolic action has led to the investigation of the use of teriparatide for the improvement of bone quality. Apart from the enhancement of fracture union, teriparatide has been extensively studied in the promotion of fusion rate after spinal fusion. This study summarizes the preclinical and clinical results of the off-label use of teriparatide in the spine, and specifically its intermittent administration after instrumented spinal arthrodesis along with its impact on the spinal bone quality and spinal bone mineral density

Impact of occupational stress on irritable bowel syndrome pathophysiology and potential management in active duty noncombat Greek military personnel: a multicenter prospective survey.

INTRODUCTION Irritable bowel syndrome (IBS) is one of the gut-brain axis interaction disorders. It has global distribution with varying prevalence and particular financial and psychological consequences. IBS has been associated with stress and anxiety, conditions that are usually prevalent in the army. There are scarce data investigating the impact of IBS on noncombat active duty military without reports of Greek military or stress in the occupational environment. MATERIALS AND METHODS The main exclusion criteria in our noncombat military multicenter prospective survey were gastrointestinal pathologies, malignancies, hematochezia, recent infections and antibiotics prescription, and pregnancy. Questionnaires included a synthesis of baseline information, lifestyle, and diet, psychological and stress-investigating scales and the IBS diagnosis checklist. Hospital Anxiety and Depression Scale and Rome IV criteria were utilized. RESULTS Among 1605 participants included finally, the prevalence of IBS was 8% and 131 cases were identified. Women were more vulnerable to IBS, although male sex was prevalent at a ratio of 3.5 : 1 (male:female) in the entire sample. The mean age of all participants was 23.85 years; most of the IBS patients were older than thirty. Abnormal anxiety scores and high levels of occupational stress were related to an IBS diagnosis. DISCUSSION This prospective multicenter survey showed, for the first time, the potential impact of occupational stress on IBS in active duty noncombat Greek Military personnel. The diagnosis of IBS by questionnaire is a quick, affordable way that can upgrade, by its management, the quality of life and relieve from the military burden. Our results are comparable with previous studies, although large-scale epidemiological studies are required for the confirmation of a possible causative relationship

Legionella spp. Colonization on Non-Passenger Ships Calling at Belgian Ports

The association of cases of Legionnaires’ disease and ships has been well documented. Results from potable water samples collected for microbiological analysis during SSC inspections conducted from 2010 to 2018 at Belgian ports were analyzed in order to evaluate the level of colonization on non-passenger ships. Results indicate a high degree of colonization (77.2% of the ships were found to be colonized with Legionella spp. at least once) and further analysis is recommended to examine possible factors associated with colonization. Inspections for issuance of SSC should focus on water safety and prevention of Legionnaires’ disease

Potable Water Quality on Non-Passenger Ships Calling Belgian Ports

Waterborne disease due to the microbial contamination of potable water onboard ships is a potential threat for seafarers. The results from the samples collected at Belgian ports from 2010 to 2018 during inspections of non-passenger ships are used to evaluate the microbiological and chemical quality of potable water. A small proportion of the samples was found positive for indicator organisms (7.5%), indicating the lack of proper disinfection and possible contamination. Further analyses and risk assessments are recommended for examining possible contributing factors. Inspections for the issuance of SSC should focus on water safety and the prevention of waterborne diseases

Potable Water Quality on Non-Passenger Ships Calling Belgian Ports

Waterborne disease due to the microbial contamination of potable water onboard ships is a potential threat for seafarers. The results from the samples collected at Belgian ports from 2010 to 2018 during inspections of non-passenger ships are used to evaluate the microbiological and chemical quality of potable water. A small proportion of the samples was found positive for indicator organisms (7.5%), indicating the lack of proper disinfection and possible contamination. Further analyses and risk assessments are recommended for examining possible contributing factors. Inspections for the issuance of SSC should focus on water safety and the prevention of waterborne diseases