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Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease
International audienceHighlights d Renal glomerulogenesis implies the separation of vascular and urinary poles (VP/UP) d Pole separation is due to a protuberance whose emergence is controlled by HNF1B d The lack of the protuberance leads to UP trapping/ constriction inside the VP d UP constriction prevents primary urine outflow and gives rise to glomerular cyst