11 research outputs found
Co-Transplantation of Cord Blood with Wharton's Jelly Derived Umbilical Cord – Mesenchymal Stem Cell S (UC-MSC) Improves Short Term Myeloid Engraftment into NOD/SCID/IL-2Rγnull mice
Effective Mobilization of Mesenchymal Stem Cells in C57BL/6 Mice Utilizing Single Agent Plerixafor (AMD3100) or in Combination with Neupogen (G-CSF)
Despite the Use of the Combination of G-CSF and Plerixafor for Stem Cell Mobilization, One Third of the Patients with Lymphoma Were Still “Poor Mobilizer” Using the Criteria Recently Proposed by GITMO (< 2.0 X 106 CD 34 + Cells Per Kg in ≤ 3 Apheresis)
Mobilization of hematopoietic stem and progenitor cells in mice
Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental 'niche' (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.</p