Interior maps in posterior pareital cortex

The posterior parietal cortex (PPC), historically believed to be a sensory structure, is now viewed as an area important for sensory-motor integration. Among its functions is the forming of intentions, that is, high-level cognitive plans for movement. There is a map of intentions within the PPC, with different subregions dedicated to the planning of eye movements, reaching movements, and grasping movements. These areas appear to be specialized for the multisensory integration and coordinate transformations required to convert sensory input to motor output. In several subregions of the PPC, these operations are facilitated by the use of a common distributed space representation that is independent of both sensory input and motor output. Attention and learning effects are also evident in the PPC. However, these effects may be general to cortex and operate in the PPC in the context of sensory-motor transformations

IMPACT OF SPATIAL PRICE DISCRIMINATION WITHIN FLORIDA DAIRY COOPERATIVES

The trend toward deregulation and the relatively high prices in the Florida milk market have increased competition for milk supplies between Florida dairy cooperatives (FDCs) and other cooperatives like Dairymen Incorporated and Southern Milk Sales. Because of the increased competition in the Florida markets, the FDCs may need to implement a discriminatory spatial pricing policy. The discriminatory pricing policy allows the FDCs to expand their membership by absorbing some of the transportation cost of producers in distant locations that would otherwise be independent producers or members of competing cooperatives. Spatial pricing policies are analyzed to determine the effects of discriminatory pricing on the blend price, average aggregate revenue of cooperative members, and total costs and quantity of milk imports. The results of this study show that a nondiscriminatory pricing policy maximizes the cooperative members' blend price and average aggregate revenue. However, if the FDCs were able to increase the price by $.50 as a result of using spatial price discrimination to gain market power, spatial price discrimination would maximize average revenue and blend price.Demand and Price Analysis,

THE ECONOMICS OF MANAGING WILDLIFE DISEASE

The spread of infectious disease among and between wild domesticated animals has become a major problem worldwide. Upon analyzing the dynamics of wildlife growth and infection when the disease animals cannot be identified separately from healthy wildlife prior to the kill, we find that harvest-based strategies alone have no impact on disease transmission. Other controls that directly influence disease transmission and/or mortality are required. Next, we analyze the socially optimal management of infectious wildlife. The model is applied to the problem of bovine tuberculosis among Michigan white-tailed deer, with non-selective harvests and supplemental feeding being the control variables. Using a two-state linear control model, we find a two-dimensional singular path is optimal (as opposed to a more conventional bang-bang solution) as part of a cycle that results in the disease remaining endemic in the wildlife. This result follows from non-selective harvesting and intermittent wildlife productivity gains from supplemental feeding.Resource /Energy Economics and Policy,

ALTERNATIVE FLUID MILK PROCUREMENT SYSTEMS FOR FLORIDA DAIRY FARMERS

This article evaluates the effects of alternative fluid milk procurement strategies on the aggregate net revenue of Florida cooperative members. They are (1) supplemental milk obtained from import sources, (2) supplemental milk obtained from a supply plant, (3) increased supply as a result of an expanded production area, and (4) supplemental milk obtained through pooling arrangements with regional dairy cooperatives. The final ranking of a scenario appears to be dependent primarily on the total cost of exports within the model. The optimal procurement strategy for Florida cooperatives should concentrate on reducing the quantity of surplus milk.Cooperative, Exports, Imports, Net revenue, Pooling, Procurement, Livestock Production/Industries,

How to Measure Group Selection in Real-world Populations

Multilevel selection and the evolution of cooperation are fundamental to the formation of higher-level organisation and the evolution of biocomplexity, but such notions are controversial and poorly understood in natural populations. The theoretic principles of group selection are well developed in idealised models where a population is neatly divided into multiple semi-isolated sub-populations. But since such models can be explained by individual selection given the localised frequency-dependent effects involved, some argue that the group selection concepts offered are, even in the idealised case, redundant and that in natural conditions where groups are not well-defined that a group selection framework is entirely inapplicable. This does not necessarily mean, however, that a natural population is not subject to some interesting localised frequency-dependent effects – but how could we formally quantify this under realistic conditions? Here we focus on the presence of a Simpson’s Paradox where, although the local proportion of cooperators decreases at all locations, the global proportion of cooperators increases. We illustrate this principle in a simple individual-based model of bacterial biofilm growth and discuss various complicating factors in moving from theory to practice of measuring group selection

Is the anisotropy of the upper critical field of Sr2_2RuO4_4 consistent with a helical pp-wave state?

We calculate the angular and temperature $T$ dependencies of the upper critical field $H_{c2}(\theta,\phi,T)$ for the $C_{4v}$ point group helical $p$-wave states, assuming a single uniaxial ellipsoidal Fermi surface, Pauli limiting, and strong spin-orbit coupling that locks the spin-triplet $\vec{\bf d}$-vectors onto the layers. Good fits to the Sr$_2$RuO$_4$ $H_{c2,a}(\theta,T)$ data of Kittaka {\it et al.} [Phys. Rev. B {\bf 80}, 174514 (2009)] are obtained. Helical states with $\vec{\bf d}(\vec{\bf k})=k_x\vec{\bf x}-k_y\vec{\bf y}$ and $k_y\vec{\bf x}+k_x\vec{\bf y}$ (or $k_x\vec{\bf x}+k_y\vec{\bf y}$ and $k_y\vec{\bf x}-k_x\vec{\bf y}$) produce $H_{c2}(90^{\circ},\phi,T)$ that greatly exceed (or do not exhibit) the four-fold azimuthal anisotropy magnitudes observed in Sr$_2$RuO$_4$ by Kittaka {\it et al.} and by Mao {\it et al.} [Phys. Rev. Lett. {\bf 84}, 991 (2000)], respectively.Comment: 5+ pages, 4 figures, submitted as a Fast Track Communication to J. Phys. Condens. Matte

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels

Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly conserved aromatic residues in the pore-lining S6 segment of the fourth homologous domain of the channel. We tested whether channel inhibition was facilitated by an electrostatic attraction between lidocaine and {pi} electrons of the aromatic rings of these residues, namely a cation-{pi} interaction. To this end, we used the in vivo nonsense suppression method to incorporate a series of unnatural phenylalanine derivatives designed to systematically reduce the negative electrostatic potential on the face of the aromatic ring. In contrast to standard point mutations at the same sites, these subtly altered amino acids preserve the wild-type voltage dependence of channel activation and inactivation. Although these phenylalanine derivatives have no effect on low-affinity tonic inhibition by lidocaine or its permanently charged derivative QX-314 at any of the substituted sites, high-affinity use-dependent inhibition displays substantial cation-{pi} energetics for 1 residue only: Phe1579 in rNaV1.4. Replacement of the aromatic ring of Phe1579 by cyclohexane, for example, strongly reduces use-dependent inhibition and speeds recovery of lidocaine-engaged channels. Channel block by the neutral local anesthetic benzocaine is unaffected by the distribution of {pi} electrons at Phe1579, indicating that our aromatic manipulations expose electrostatic contributions to channel inhibition. These results fine tune our understanding of local anesthetic inhibition of voltage-gated sodium channels and will help the design of safer and more salutary therapeutic agents

Late time cosmological phase transitions 1: Particle physics models and cosmic evolution

We described a natural particle physics basis for late-time phase transitions in the universe. Such a transition can seed the formation of large-scale structure while leaving a minimal imprint upon the microwave background anisotropy. The key ingredient is an ultra-light pseudo-Nambu-Goldstone boson with an astronomically large (O(kpc-Mpc)) Compton wavelength. We analyze the cosmological signatures of and constraints upon a wide class of scenarios which do not involve domain walls. In addition to seeding structure, coherent ultra-light bosons may also provide unclustered dark matter in a spatially flat universe, omega sub phi approx. = 1