23 research outputs found

    Variants of HCV entry factors found in HIV-infected, HCV-uninfected patients but not in HIV/HCV-coinfected controls.

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    <p><sup>a</sup> Database single nucleotide polymorphism. <sup>b</sup> 1000 Genomes database. <sup>c</sup> refSNP reference identification number of single nucleotide polymorphism. <sup>d</sup> Not attributed. <sup>e</sup> Minor allele frequency. <sup>f</sup> Intravenous drug users.</p

    Schematic representation of of CLDN6, CLDN9, OCLN and SCARB1 genes.

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    <p>Exons are represented by numbered gray rectangles and introns or non coding regions by double blue lines. Positions of primers pairs used for direct genomic sequencing are shown. Reference sequences of the transcripts are NM_021195.4 (CLDN6), NM_020982.3 (CLDN9), NM_002538.3 (OCLN) and NM_005505.4 (SCARB1). The numbering starts at the first base of the initiation codon ATG, and stops at the first base of the termination codon of the corresponding transcripts. The sequences of corresponding primers are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142698#pone.0142698.t001" target="_blank">Table 1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142698#pone.0142698.t002" target="_blank">Table 2</a>. F: Forward primer, R: Reverse primer, LR: Long Range PCR primer. SNPs identified by direct genomic sequencing are indicated, in red SNPs specific of the case population HIV+ HCV-.</p
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