HLA-A, HLA-G UTRs, -G, -E, -H and -F allelic frequencies in 191 voluntary blood donors from southeastern France.

<p>HLA-A, HLA-G UTRs, -G, -E, -H and -F allelic frequencies in 191 voluntary blood donors from southeastern France.</p

Analysis of two-loci global linkage disequilibrium (GLD) between HLA-E (defined at 8 (8d) or 4-digits (4d)) and HLA-A, -H, -G, HLA-G UTRs and -F.

<p>Analysis of two-loci global linkage disequilibrium (GLD) between HLA-E (defined at 8 (8d) or 4-digits (4d)) and HLA-A, -H, -G, HLA-G UTRs and -F.</p

HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.

<p>HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.</p

HLA-E, -H, -G, -F and HFE relative location and distance from HLA-A on chromosome 6.

<p>HLA-E, -H, -G, -F and HFE relative location and distance from HLA-A on chromosome 6.</p

Two-loci haplotypes with a frequency higher than 3% (2% for HLA-A); obs: estimated frequency; exp: expected frequency; stdres: standardized residual–in grey if significant, i.e. corresponding to an absolute value above 2.

<p>Two-loci haplotypes with a frequency higher than 3% (2% for HLA-A); obs: estimated frequency; exp: expected frequency; stdres: standardized residual–in grey if significant, i.e. corresponding to an absolute value above 2.</p

Comparison between UTR-2 alleles G*01:05N/G*01:05N (n = 5 141.4±13.9 UI/ml) and all except G*01:05N/G*01:05N (n = 9 129.5±16.8 UI/ml).

<p>Statistical comparison was based on Kruskal-Wallis one-way ANOVA followed by Dunn post-hoc test.</p

Correlation between sHLA-G levels and age in women.

<p>Statistical correlation between age and sHLA-G levels was tested using Spearman's rank test (rS = −0.1905, p = 0.004).</p

Frequencies (Fq) and absolute value (N) of coding HLA-G alleles, 5′URR and 3′UTR SNPs in the Malian population.

<p>Results are compared with previously published results on VBMD <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082517#pone.0082517-DiCristofaro1" target="_blank">[41]</a>. Statistical differences between the two populations frequencies were measured using a chi-squared test (NS: not significant; *: p<0.05; **: p<0.01; ***: p<0.001).</p

Two-locus linkage disequilibrium (LD) in the Malian population (n = 230) between polymorphisms in the 5′URR (−725 C/G or T; −716 G/T; −201 G/A and −56 C/T), in the coding region (codons 13C/T; 31 A/T; 54 A/G; 110 C/A; 130 C/T; 159 T/C; 219 C/T and 258 C/T) and in the 3′UTR (<i>ins/del</i> exon 8; 3142 C/G; 3187 G/A and 3196 C/G).

<p>Statistical significance (p value at junction between two loci) is indicated by color (light gray: p<0.05, gray: p<0.01 and black p<0.001).</p

Comparison between UTR-2 (n = 103) and non-UTR-2 (n = 116) individuals related to sHLA-G production.

<p>Statistical comparison was based on Mann-Whitney t-test. (UTR-2 137.5±30.6 UI/ml vs. all except UTR-2 148.2±30.7 UI/ml). When six outer points were excluded (238.6 UI/ml, 217.6 UI/ml and 53.8 UI/ml for UTR-2; 242.2 UI/ml, 229.8 UI/ml and 226.5 UI/ml for non-UTR-2) UTR-2 individuals still displayed significantly lower values (p<0.05).</p