Shape of Fluorescent signals in the perilesional lung and the associated targeted lesions.

<p>^a. Comparison of the percentage of each shape between perilesional lung parenchyma and targeted lesions. Statistical analysis using the Pearson χ². statistical significance defined as * p<0,01, ** p<0,001, ***p<0,0001.</p><p>^b. Comparison of the percentage of each shape between NSLC and non-tumoral lesions and lung metastases. Statistical analysis using the Pearson χ². Statistical significance defined as ^§p = 0,02, ^§§p<0,01, ^§§§p<0,001.</p><p>NSCLC: Non Small Cell Lung Cancer. PB: Photobleaching.</p

Patients’ characteristics.

<p>^a. Comparison of NSCLC with non-tumoral lesions using the Pearson χ² or the Fischer exact test when necessary. Statistical significance p<0,05.</p><p>^b. Comparison of NSCLC with lung metastases using the Pearson χ² or the Fischer exact test when necessary. Statistical significance p<0,05.</p><p>NA: Not applicable. NSCLC: Non Small Cell Cancer.</p><p>Patients’ characteristics.</p

(A) Comparison of mean Imax of the targeted lesions. (B) Comparison of mean Imax of perilesional lung in the different populations.

<p>Mean Imax was calculated with the mean Imax of each lesion: 60 NSCLC, n = 24 non-tumoral lesions, 27 metastases. Mean Imax of perilesional lung was calculated separately for each population. Statistical analysis were realised with the Mann-Whitney test, SPSS 17.0 package (SPSS, Chicago, IL). Statistical significance defined as p<0,05. NSCLC: Non Small Cell Lung Cancer. SD: Standard Derivation.</p

Difference of Mean Imax in absolute value of non-tumoural lesions and non small cell lung cancer with the associated perilesional lung parenchyma.

<p>Each dot was calculated with the mean Imax of the five measurements performed on the non-tumoural lesions (n = 24) and NSCLC (n = 60). The black bar corresponds to the median value of each subgroup. NSCLC: Non Small Cell Lung Cancer. NT: Non tumoural.</p

Percentage of shapes of Fluorescent Signals observed in perilesional lung parenchyma, NSCLC, non-tumoral lesions and lung metastases.

<p>Comparison of the percentage of each shape between perilesional lung and targeted lesions. Statistical analysis using the Pearson χ² test. Statistical significance defined as * p<0,01, ** p<0,001, ***p<0,0001. Comparison of the percentage of each shape between NSCLC and non-tumoral lesions and lung metastases. Statistical analysis using the Pearson χ². Statistical significance defined as ^§p = 0,02, ^§§p<0,01, ^§§§p<0,001. NSCLC: Non Small Cell Lung Cancer.</p

Comparison of Imax of perilesional lung and their associated lesions.

<p>^a. Mann-Whitney test, SPSS 17.0 package (SPSS, Chicago, IL). Statistical significance defined as p<0,05.</p><p>^b. Deflated Perilesional tissue.</p><p>^c. Inflated Perilesional tissue, 32 samples available.</p><p>NSCLC: Non Small Cell Lung Cancer.</p><p>Comparison of Imax of perilesional lung and their associated lesions.</p

Sensitivity and specificity for primary lung cancer.

<p>The sensitivity and specificity were respectively of 77% and 92%. The positive and negative predictive values were respectively of 96 and 61%. NSCLC: Non Small Cell Lung Cancer. PB: Photobleaching.</p

Shape of fluorescent signals.

<p>Shape of fluorescent signals.</p

Flowchart.

<p>Flowchart.</p