Experimental regimens used for both short-term and long-term guinea pig studies.

<p>Experimental regimens used for both short-term and long-term guinea pig studies.</p

Comparison of Mean Days to Death of various treatment groups of guinea pigs.

<p>Mean Days to Death (MDD) was determined by dividing the summed total number of surviving days of each treatment group with the number of animals/group. Results are expressed as means±SEM of eight animals/group. Note: MDD for BCG/Ad groups may have been underestimated as 40–60% of animals in these treatment groups were still surviving at the time study termination (74 weeks). **p≤0.01, *p≤0.05 compared to saline control or between BCG and BCG/Ad i.n.</p

Kaplan-Meier curves of percent survival of <i>M.tb</i>-infected guinea pigs over the course of 74 weeks post-challenge.

<p>Groups of guinea pigs (eight animals per group) were treated as depicted in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005856#pone-0005856-g001" target="_blank">Fig. 1B</a> and their survival rate was determined on a weekly basis up to 74 weeks when the entire study was terminated. p≤0.01 BCG, BCG/Ad i.n and BCG/Ad i.m compared to saline control; p≤0.05 BCG vs. BCG/Ad i.n; p≤0.1 BCG vs. BCG/Ad i.m.</p