Homozygote genotype of inheritance for association of 27 SNPs previously associated with sudden cardiac death and in this study investigated for association with ventricular fibrillation before ST-segment elevation myocardial infarction.

<p>Homozygote genotype of inheritance for association of 27 SNPs previously associated with sudden cardiac death and in this study investigated for association with ventricular fibrillation before ST-segment elevation myocardial infarction.</p

Baseline characteristics of the cohort.

<p>Baseline characteristics of the cohort.</p

Baseline characteristics of study participants by cohort.

<p>Values correspond to N (%) or mean (standard deviation). The standard deviation of each gene score in each cohort is 1 due to the method of standardization used.—AGES, indicates the Age, Gene/Environment Susceptibility—Reykjavik study; ARIC, Atherosclerosis Risk in Communities; FHS, Framingham Heart Study; MDCS, Malmö Diet and Cancer study; RS, Rotterdam Study; WGHS, Women's Genome Health Study; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDLc, high density lipoprotein cholesterol; LDLc, low density lipoprotein cholesterol; LVH, left ventricular hypertrophy; NA, not available, * not fasting.</p

Previously discovered multivariable-adjusted cohort-specific Hazard Ratios and 95% Confidence Intervals of the risk of atrial fibrillation associated with blood lipids.

<p>Associations are per 1 standard deviation increase unless noted. ARIC, Atherosclerosis Risk in Communities; FHS, Framingham Heart Study; WHS, Women's Health Study; MESA, Multi-Ethnic Study of Atherosclerosis; CHS, Cardiovascular Health Study.</p

Multivariable adjusted Hazard Ratios (95% confidence interval) of Atrial Fibrillation of a 1 Standard Deviation Increase in Lipid Gene Score, by Cohort.

<p>HR, Hazard Ratio; CI, Confidence interval; NA, not available. -AGES, indicates the Age, Gene/Environment Susceptibility—Reykjavik study; ARIC, Atherosclerosis Risk in Communities; FHS, Framingham Heart Study; MDCS, Malmö Diet and Cancer study; RS, Rotterdam Study; WGHS, Women's Genome Health Study. Model 1: Cox proportional hazard model adjusted for age, sex and study center, if appropriate. Model 2: Model 1 + education, height, smoking status, body mass index, systolic blood pressure, diastolic blood pressure, use of antihypertensive medication, diabetes, left ventricular hypertrophy, previous stroke, previous coronary heart disease and previous heart failure. Model 3: Model 2 + adjusted for continuous lipid levels and lipid medication use.</p

Regional association plots for the two associated SNPs with SCD.

<p>Each SNP is plotted with respect to its chromosomal location (x-axis) and –log₁₀P-value (y-axis on the left). The spikes indicate the recombination rate (y-axis on the right) at that region of the chromosome.</p

Manhattan plot of associated findings.

<p>Data is displayed as –log₁₀P values against chromosomal location for the 119,117 SNPs that were included in the statistical analysis. The dotted line represents the conservative significance threshold of P = 4.2×10⁻⁷. The two loci that showed an association at this level are plotted in red.</p

Summary of the two loci associated with SCD.

<p>Chr, chromosome; SE, standard error; OR, odds ratio.</p