IMPACTS OF BINDER AND DISINTEGRANT ON DETAM II SOYBEAN (GLYCINE MAX (L.) MERR) TABLET MADE BY DRY GRANULATION

Keywords: Detam II black soybean (Glycine max (L.) Merr), Tablet, Binder, Disintegrant, Disintegration time Black soybean (Glycine max L. Merr) Detam II Variety has a scavenging activity and total phenolic compound higher than yellow soybean. As a natural compound, the flow properties of black soybean (Glycine max (L.) Merr) Detam II powder is poor due to its high content of moisture, so it must be made by dry granulation method. Dry binder and disintegrant have opposite functions on tablets formula where one serves to increase consolidation between particles while other accelerate the disintegration time as the rate limiting step of dissolution. The effects of disintegrant and dry binder variation on the physical characteristics of black soybean tablets have been observed. The variations of polyvinylpyrrolidone (PVP)-K30 combined with Plasdone S-630 were used as binders, while sodium starch glycolate (SSG) was used as a disintegrant. Approximately 4% of PVP-K30 as a single binder in the formula component provides better hardness and friability value of tablets, but the disintegration time was longer than other formulas. The amount of SSG used was increased to 4 and 8%, respectively in the formula component. 4% was the ideal amount of SSG as a disintegrant to get the best physical tablet characteristics and also disintegration time, about 4.45 minutes. Increasing the amount of SSG has no significant effect on the disintegration time even tends to slow down