Putatively functional SNPs imputed from the ATM locus associated with the risk of NHL.

<p>OR = odds ratio; CI = confidence interval; TFBS = transcription factor binding site; UTR = untranslated region.</p><p>*Correlated tSNP for rs228595 is rs611646; all other SNPs are correlated with the tSNP rs419716.</p

Association analysis of genetic variants in DNA repair genes with the risk of major NHL subtypes.

<p>DLBCL = diffuse large B-cell lymphoma; FL = follicular lymphoma; SLL/CLL = small lymphocytic lymphoma/chronic lymphocytic leukemia; OR = odds ratio; CI = confidence interval.</p

The results of association analysis, displayed as Manhattan plot, after imputation of 28 SNPs genotyped in both stage 1 and 2, which tag 11 DNA repair genes that showed association with NHL risk in our study.

<p>The SNPs and genes are ordered by chromosomal position (x-axis). The associations are displayed as –log₁₀(p-value) for each SNP. Red dots represent fifteen tagging SNPs that were genotyped in our study and were associated with NHL risk. Green dots represent tagging SNPs that were genotyped in our study and that showed no association with NHL. Blue markers represent SNPs imputed by IMPUTE from 1KG. The red dotted line defines the threshold of p-value <0.05. * indicates an associated SNP with a putatively functional impact; non-synonymous coding change or SNP mapping in: transcription factor binding site, H3K4Me1 chromatin mark, DNaseI hypersensitivity cluster, 5′UTR, 3′UTR.</p

Association analysis of rs1805812 x rs625245 interactions between <i>MRE11A</i> and <i>NBS1</i> with the risk of NHL.

<p>OR = odds ratio; CI = confidence interval.</p

Association analysis of genetic variants in DNA repair genes with the risk of NHL.

<p>OR = odds ratio; CI = confidence interval.</p