Additional file 1: of Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)

Supplementary information. Table S1: Primer sequences. Table S2: List of cytokines and their expression. (DOCX 14 kb

Baseline data, medical history, biomarkers and cardiac work up in patients with FD in relation to cardiac troponin I elevation and normal values.

<p>*a small fibre dysfunction was proved by quantitative sensory testing or by skin biopsy.</p>†<p>measurement end-diastolic in the posterior wall of the left ventricle.</p>$<p>Arrhythmia was considered if one of the following conditions was detected: persistent or intermittent atrial fibrillation of flatter, sustained tachycardia (heart rate ≥100/minute for more than 30 seconds), non-sustained tachycardia (heart rate ≥100/minute for less than 30 seconds in at least 3 subsequent hear cycles), incomplete bundle branch block (QRS-duration: 100–119 ms) or complete bundle branch block (QRS-duration ≥120 ms).</p>§<p>lower level of quantification.</p

Cardiac work up in patient 2.

<p>A+B: Coronary angiography (A: right coronary artery; B: left coronary artery) demonstrating no relevant pathology. C+D: Cardiac MRI showing increase in myocardial wall thickness (C) and pathological late gadolinium enhancement (D, arrow). E: Myocardial biopsy revealing strong accumulation of Gb_3, as indicated by numerous vacuoles within the cardiomyocytes (arrow).</p

cTNI-values in 3 patients with Fabry disease.

<p>cTNI-values in 3 patients with Fabry disease.</p

Synopsis of alpha-galactosidase gene mutations in 14 patients included in the study.

<p>Synopsis of alpha-galactosidase gene mutations in 14 patients included in the study.</p

Elaboration of a Highly Porous Ru^II,II Analogue of HKUST‑1

When the dinuclear Ru^II,II precursor [Ru₂(OOCCH₃)₄] is employed under redox-inert conditions, a Ru^II,II analogue of HKUST-1 was successfully prepared and characterized as a phase-pure microcrystalline powder. X-ray absorption near-edge spectroscopy confirms the oxidation state of the Ru centers of the paddle-wheel nodes in the framework. The porosity of 1371 m²/mmol of Ru^II,II-HKUST-1 exceeds that of the parent compound HKUST1 (1049 m²/ mmol)

Video abstract for publication: Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial

This is a presentation from the lead author of this peer-reviewed original research article. This was a multicenter, double-blind clinical trial investigating the efficacy and safety of Traumeel gel versus placebo gel and non-inferiority versus 1% diclofenac gel, applied 3×/day for 7 days after acute lateral ankle sprain (EudraCT Number: 2016-004792-50). This video abstract was published together with original article (see the link to the publication below).</p

Microarray-Based Genotyping and Clinical Outcomes of <i>Staphylococcus aureus</i> Bloodstream Infection: An Exploratory Study

<div><p>The clinical course of <i>Staphylococcus aureus</i> bacteremia varies extensively. We sought to determine the relationship between genetic characteristics of the infecting pathogen and clinical outcomes in an exploratory study. In two study centers, 317 blood culture isolates were analyzed by DNA microarray and <i>spa</i> genotyping. By uni- and multivariate regression analyses associations of genotype data with 30-day all-cause mortality, severe sepsis/septic shock, disseminated disease, endocarditis, and osteoarticular infection were investigated. Univariate analysis showed significant association between <i>S. aureus</i> genes/gene-clusters or clonal complexes and clinical endpoints. For example CC15 was associated with 30-day mortality and CC22 with osteoarticular infection. In multivariate analysis methicillin resistance (<i>mecA,</i> OR 4.8 [1.43–16.06]) and the beta-lactamase-gene (<i>bla</i>, OR 3.12 [1.17–8.30]) remained independently associated with 30-day mortality. The presence of genes for enterotoxins (<i>sed/sej/ser</i>) was associated with endocarditis (OR 5.11 [1.14–18.62]). Host factors such as McCabe classification (OR 4.52 [2.09–9.79] for mortality), age (OR 1.06 [1.03–1.10] per year), and community-acquisition (OR 3.40 [1.31–8.81]) had a major influence on disease severity, dissemination and mortality. Individual genotypes and clonal complexes of <i>S. aureus</i> can only partially explain clinical features and outcomes of <i>S. aureus</i> bacteremia. Genotype-phenotype association studies need to include adjustments for host factors like age, comorbidity and community-acquisition.</p></div

2813738.pdf

Supplemental Documen

Prevalence of major virulence factors and resistance determinants in 317 SAB isolates.

<p>Genes encoding exfoliative toxin serotype A and B (<i>etA</i>, <i>etB</i>), exfoliative toxin D (<i>etD</i>), PVL (<i>lukF-PV, lukS-PV</i>) were detected in <5% of isolates. Fusidic acid resistance (<i>far1</i>), surface protein involved in biofilm formation (<i>bap</i>) genes and capsule type 1 genes (capH1/I1/J1/K1) were not detected.</p><p>Genes encoding staphylococcal superantigen-like protein-1,-2,-4,-5,-7,-9,-10 (<i>ssl</i>-genes), clumping factor A/B (<i>clfA/B</i>), hemolysin alpha (<i>hla</i>), aureolysin (<i>aur</i>), intercellular adhesion protein A/C (<i>icaA</i>, <i>icaC</i>) and biofilm PIA synthesis protein D (<i>icaD</i>), fibronectin-binding protein A (<i>fnbA</i>), fibrinogen binding protein (<i>fib</i>) were detected in >95% of isolates. The hemolysin delta gene (<i>hld</i>) was found in 100% of isolates.</p