Frequencies (%) of control region polymorphisms >5% in patients with CNV and in controls as well as the corresponding odds ratios and 95% confidence intervals.

a<p>mtDNA = mitochondrial DNA.</p>b<p>CNV = choroidal neovascularisation.</p>c<p>n: number of individuals with the respective polymorphism.</p>d<p>P-value: Pearson chi-square or Fisher's exact test.</p>e<p>CI = confidence interval.</p>f<p>adjusted for age and sex by logistic regression analysis.</p

Comparison of age-related macular degeneration case-control studies in the literature with the present study.

a<p>mtDNA = mitochondrial DNA.</p>b<p>According to PhyloTree.org <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030874#pone.0030874-vanOven1" target="_blank">[21]</a>.</p>c<p>P-values: present study: adjusted for age and sex. Jones et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030874#pone.0030874-Jones1" target="_blank">[12]</a>: adjusted for age, sex and current smoking. Canter et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030874#pone.0030874-Canter1" target="_blank">[13]</a>: adjusted for sex and three nuclear polymorphisms (CFH-Complement Factor H gene, rs1061170; LOC387715, rs10490924; APOE, ApoE2 allele). Udar et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030874#pone.0030874-Udar1" target="_blank">[14]</a>: no adjustment. SanGiovanni et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030874#pone.0030874-SanGiovanni1" target="_blank">[15]</a>: adjusted for age, sex and smoking.</p>d<p>CI = confidence interval.</p

Characteristics of the study populations.

a<p>CNV = choroidal neovascularization.</p>b<p>AMD = age-related macular degeneration.</p>c<p>SD = standard deviation.</p

Frequencies (%) of mitochondrial haplogroups in Caucasian patients with CNV and in controls.

a<p>CNV = choroidal neovascularization.</p>b<p>P-value: Pearson chi-square or Fisher's exact test.</p>c<p>Haplogroups that could not be assigned to one of the nine major European haplogroups by the SNP combination.</p