Sequence, number of amino acids and molecular weight of human IGF-I, three human pro-IGF-I isoforms, full-length MGF, Human MGF, Goldspink-MGF and Long R3-IGF-I (modified from Thevis et al. (6)).

<p>Sequence, number of amino acids and molecular weight of human IGF-I, three human pro-IGF-I isoforms, full-length MGF, Human MGF, Goldspink-MGF and Long R3-IGF-I (modified from Thevis et al. (6)).</p

Stimulatory activity of the insulin receptor-B (IR-B).

<p><b>A:</b> Comparison of full-length MGF (red points and line) and insulin (green points and line). <b>B:</b> Comparison of Human MGF (red points and line) and insulin) (green points and line). <b>C:</b> Comparison of Goldspink-MGF (red points and line) and insulin (green points and line). Dose-response curves ranged from 0.03125 nmol/L to 500 nmol/L. For bioactivity measurements means ± SEM and signal-to-noise ratios are presented. <b>A-C:</b> Each point represents the mean value ± SEM of at least three independent experiments. P = P-value when comparing overall differences in fold stimulation between two ligands.</p

Stimulatory activity of the insulin receptor-A (IR-A).

<p><b>A</b>: Comparison of full-length MGF (red points and line) and insulin (green points and line). <b>B:</b> Comparison of Human MGF (red points and line) and insulin) (green points and line). <b>C:</b> Comparison of Goldspink-MGF (red points and line) and insulin (green points and line). Dose-response curves ranged from 0.03125 nmol/L to 500 nmol/L. For bioactivity measurements means ± SEM and signal-to-noise ratios are presented. <b>A-C</b>: Each point represents the mean value ± SEM of at least three independent experiments. P = P-value when comparing overall differences in fold stimulation between two ligands.</p

Table_1_Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors.docx

<p>Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities.</p><p>Design: Cross sectional, multicentric.</p><p>Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent. Age, sex, IGF-1 concentrations, comorbidities, treatment modalities and pituitary insufficiency were documented.</p><p>Results: Acromegalic patients or specific patient-subgroups were more agreeable, neurotic, exploitable/permissive, introverted/socially avoidant, non-assertive/insecure, nurturant and less open to experience, cold/denying, domineering, compared to normal values from the healthy population (controls). Multivariable analysis demonstrated that these overall results were due to the specific patient subgroups as patients on chronic medication, with arthrosis and pituitary insufficiency. Disease activity was only associated with the trait nurturant. Higher scores for introversion were associated with arthrosis. Lower domineering was independent of any disease- or treatment related variable or comorbidity. The GBB inventory showed overall higher scores in patients, with higher scores for exhaustion and general complaints being associated with pituitary insufficiency, coronary heart disease and history of malignancy in the multivariable analysis. Joint complaints were independent of any disease- or treatment- related variable.</p><p>Conclusions: We define new aspects of a distinct neuropsychological profile in patients with acromegaly, which are largely independent of disease activity. Chronic physical complaints are more pronounced in patients than in controls, with exhaustion and general complaints showing no association with disease activity.</p

Table_2_Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors.docx

<p>Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities.</p><p>Design: Cross sectional, multicentric.</p><p>Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent. Age, sex, IGF-1 concentrations, comorbidities, treatment modalities and pituitary insufficiency were documented.</p><p>Results: Acromegalic patients or specific patient-subgroups were more agreeable, neurotic, exploitable/permissive, introverted/socially avoidant, non-assertive/insecure, nurturant and less open to experience, cold/denying, domineering, compared to normal values from the healthy population (controls). Multivariable analysis demonstrated that these overall results were due to the specific patient subgroups as patients on chronic medication, with arthrosis and pituitary insufficiency. Disease activity was only associated with the trait nurturant. Higher scores for introversion were associated with arthrosis. Lower domineering was independent of any disease- or treatment related variable or comorbidity. The GBB inventory showed overall higher scores in patients, with higher scores for exhaustion and general complaints being associated with pituitary insufficiency, coronary heart disease and history of malignancy in the multivariable analysis. Joint complaints were independent of any disease- or treatment- related variable.</p><p>Conclusions: We define new aspects of a distinct neuropsychological profile in patients with acromegaly, which are largely independent of disease activity. Chronic physical complaints are more pronounced in patients than in controls, with exhaustion and general complaints showing no association with disease activity.</p