2° Encuentro de investigación y emprendimiento UDR Mariquita Tolima 2023

Los semilleros de investigación de la UNAD UDR Mariquita, “Creciendo en identidad, Desarrollo Rural, EIOCYD, EMPROMAR e IoT” en colaboración con el SISSU, realizaron el día 12 de mayo el 2do Encuentro de Investigación y emprendimiento como estrategia de participación ciudadana, donde se reunieron diferentes instituciones educativas y sector productivo, que han venido realizando trabajos de investigación, innovación y emprendimiento buscando contribuir al desarrollo sostenible del territorio y las comunidades que habitan en él. Las temáticas abordas en dicho encuentro pretendían contribuir a generar respuestas e inquietudes sobre las necesidades sociales, productivas y económicas de la región, con el fin de dar cumplimiento al objetivo institucional de trabajar por las comunidades y con las comunidades de manera articulada.

AMH type II receptor and AMH gene polymorphisms are not associated with ovarian reserve, response, or outcomes in ovarian stimulation

PURPOSE: Genetic variation may influence women’s response to ovarian stimulation therapy. The purpose of this study was to investigate any effects of genetic variants in the anti-Müllerian hormone (AMH) and AMH type II receptor genes on ovarian response/treatment outcomes and on current markers of ovarian reserve in individuals undergoing in vitro fertilisation (IVF) treatment. METHODS: In this prospective observational study, we genotyped the AMH c.146G>T, p.(Ile49Ser) and AMHR2 -482A>G variants in 603 unrelated women undergoing their first cycle of controlled ovarian stimulation for IVF and ICSI (intracytoplasmic sperm injection) using gonadotrophins at a tertiary referral centre for reproductive medicine. Pelvic ultrasound and blood hormone levels were taken on days 2–3 of the cycle. Genotypes were determined using TaqMan allelic discrimination assay. Regression analysis was performed to assess the relationship between the genotypes and the ovarian reserve markers (FSH, AMH, antral follicle count) and the early outcomes of response (number of oocytes retrieved and gonadotropin dose) as well as the treatment outcome (live birth). RESULTS: There were no significant associations between the variants AMH c.146G>T and AMHR2 -482A>G with ovarian response in terms of number of oocytes retrieved (p = 0.08 and p = 0.64, respectively), live births (p = 0.28 and p = 0.52) and/or markers of ovarian reserve. CONCLUSIONS: Genotyping of the AMH c.146G>T and AMHR2 -482A>G polymorphisms does not provide additional useful information as a predictor of ovarian reserve or ovarian response and treatment outcomes