Protein expression of collagen III in rat left ventricle after MI.

<p><i>A):</i> Immunoblots for collagen III and GAPDH in left ventricle (remote area). <i>B):</i> mean densitometric analysis of collagen III. Sham levels were set at 1, and all other values were normalized to Sham. All values are mean ± SD, n = 6. *p<0.05 vs. vehicle control; #p<0.05 vs. sham.</p

Protein expression of active MMP-2 and pro MMP-2 in rat left ventricle after MI.

<p><i>A):</i> Immunoblots for pro MMP-2, active MMP-2, and GAPDH in left ventricle (remote area). <i>B):</i> mean densitometric analysis of pro and active MMP-2. Sham levels were set at 1, and all other values were normalized to Sham. All values are mean ± SD, n = 6. *p<0.05 vs. vehicle control; #p<0.05 vs. sham.</p

Hemodynamic parameter changes in rats 7 days after MI. All values are mean ± SD, n = 8.

<p>MBP, mean arterial blood pressure; HR, heart rate; LVP, left ventricular systolic pressure; LVEDP, left ventricle end-diastolic pressure; ± dp/dt max, first derivative of left ventricular pressure.</p>*<p>p<0.05 vs. vehicle;</p><p>#p<0.05 vs. sham.</p

Reverse-transcription polymerase chain reaction (RT-PCR) data for endogenous expression of <i>A):</i> B1 receptor, <i>B):</i> B2 receptor, <i>C):</i> AT1 receptor, and <i>D):</i> ACE1 mRNA in rat left ventricle after MI.

<p>Sham levels were set at 1, and all other values were normalized to Sham. All values are mean ± SD, n = 6. *p<0.05 vs. vehicle control; #p<0.05 vs. sham.</p

Ratios of heart weight to body weight (HW/BW) and lung weight to body weight (LW/BW) and infarct size 7 days after MI. Values are mean ± SD, n = 8.

<p>Sham, sham-operated rats without coronary occlusion; Vehicle, without any medication; BI1, treated with B1 receptor antagonist (BI 113823); IRB, treated with AT1 receptor antagonist (irbesartan); BI1+IRB, treated with both BI 113823 and irbesartan.</p

Echocardiographic measurements of left ventricular function following myocardial infarction in rat.

<p><i>A):</i> left ventricular ejection fraction (EF), <i>B):</i> fractional shorting (FS), and <i>C):</i> wall motion. All values are mean ± SD, n = 8. *p<0.05 vs. vehicle control; #p<0.05 vs. sham. Sham, sham-operated rats without coronary occlusion; Vehicle, without any medication; BI1, treated with B1 receptor antagonist (BI 113823); IRB, treated with AT1 receptor antagonist (irbesartan); BI1+IRB, treated with BI 113823 and irbesartan.</p

Observation of burst activity from SGR1935+2154 associated to first galactic FRB with H.E.S.S.

Fast radio bursts (FRB) are enigmatic powerful single radio pulses with durations of several milliseconds and high brightness temperatures suggesting coherent emission mechanism. For the time being a number of extragalactic FRBs have been detected in the high-frequency radio band including repeating ones. The most plausible explanation for these phenomena is magnetar hyperflares. The first observational evidence of this scenario was obtained in April 2020 when an FRB was detected from the direction of the Galactic magnetar and soft gamma repeater SGR1935+2154. The FRB was preceded with a number of soft gamma-ray bursts observed by Swift-BAT satellite, which triggered the follow-up program of the H.E.S.S. imaging atmospheric Cherenkov telescopes (IACTs). H.E.S.S. has observed SGR1935+2154 over a 2 hour window few hours prior to the FRB detection by STARE2 and CHIME. The observations overlapped with other X-ray bursts from the magnetar detected by INTEGRAL and Swift-BAT, thus providing first observations of a magnetar in a flaring state in the very-high energy domain. We present the analysis of these observations, discuss the obtained results and prospects of the H.E.S.S. follow-up program for soft gamma repeaters and anomalous X-ray pulsars